Assay Detail
Binding
CHEMBL677212
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Inhibition of epidermal growth factor receptor (EGF-R)
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Discovery of 5-[5-fluoro-2-oxo-1,2- dihydroindol-(3Z)-ylidenemethyl]-2,4- dimethyl-1H-pyrrole-3-carboxylic acid (2-diethylaminoethyl)amide, a novel tyrosine kinase inhibitor targeting vascular endothelial and platelet-derived growth factor receptor tyrosine kinase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 5.00 | 5.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL13629 | — | — | 1 | 5.00 |
| CHEMBL274654 | ORANTINIB | 3.0 | 1 | - |
| CHEMBL268731 | — | — | 1 | - |
| CHEMBL430155 | — | — | 1 | - |
| CHEMBL13354 | — | — | 1 | - |
| CHEMBL13485 | SU-11652 | — | 1 | - |
| CHEMBL276711 | SEMAXANIB | 3.0 | 1 | - |
| CHEMBL267293 | — | — | 1 | - |
| CHEMBL13608 | TOCERANIB | 2.0 | 1 | - |
| CHEMBL13983 | — | — | 1 | - |
| CHEMBL13976 | — | — | 1 | - |
| CHEMBL275117 | — | — | 1 | - |
| CHEMBL535 | SUNITINIB | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL13629 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL274654 | ORANTINIB | IC50 | > | 20000.0 | nM | - |
| CHEMBL268731 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL430155 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL13354 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL13485 | SU-11652 | IC50 | > | 20000.0 | nM | - |
| CHEMBL276711 | SEMAXANIB | IC50 | > | 100000.0 | nM | - |
| CHEMBL267293 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL13608 | TOCERANIB | IC50 | > | 20000.0 | nM | - |
| CHEMBL13983 | — | IC50 | = | - | nM | - |
| CHEMBL13976 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL275117 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL535 | SUNITINIB | IC50 | > | 20000.0 | nM | - |