Assay Detail
Binding
CHEMBL677214
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Inhibition of Epidermal growth factor receptor autophosphorylation in A431 cells
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | A-431 |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Tyrosine kinase inhibitors. 16. 6,5,6-tricyclic benzothieno[3, 2-d]pyrimidines and pyrimido[5,4-b-] and -[4,5-b]ĭndoles as potent inhibitors of the epidermal growth factor receptor tyrosine kinase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 6.94 | 7.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL153206 | — | — | 1 | 7.89 |
| CHEMBL358934 | — | — | 1 | 7.48 |
| CHEMBL153573 | — | — | 1 | 7.38 |
| CHEMBL152905 | — | — | 1 | 7.07 |
| CHEMBL357570 | — | — | 1 | 7.07 |
| CHEMBL554983 | — | — | 1 | 7.03 |
| CHEMBL155278 | — | — | 1 | 7.01 |
| CHEMBL356850 | — | — | 1 | 6.77 |
| CHEMBL345988 | — | — | 1 | 6.31 |
| CHEMBL423224 | — | — | 1 | 6.20 |
| CHEMBL152984 | — | — | 1 | 6.11 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL153206 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL358934 | — | IC50 | = | 33.0 | nM | 7.48 |
| CHEMBL153573 | — | IC50 | = | 42.0 | nM | 7.38 |
| CHEMBL152905 | — | IC50 | = | 86.0 | nM | 7.07 |
| CHEMBL357570 | — | IC50 | = | 85.0 | nM | 7.07 |
| CHEMBL554983 | — | IC50 | = | 93.0 | nM | 7.03 |
| CHEMBL155278 | — | IC50 | = | 98.0 | nM | 7.01 |
| CHEMBL356850 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL345988 | — | IC50 | = | 493.0 | nM | 6.31 |
| CHEMBL423224 | — | IC50 | = | 630.0 | nM | 6.20 |
| CHEMBL152984 | — | IC50 | = | 769.0 | nM | 6.11 |