Assay Detail
Binding
CHEMBL677216
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Inhibition of autophosphorylation of EGFR in A431 cells
31
Total Activities
31
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | A-431 |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Tyrosine kinase inhibitors. 18. 6-Substituted 4-anilinoquinazolines and 4-anilinopyrido[3,4-d]pyrimidines as soluble, irreversible inhibitors of the epidermal growth factor receptor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 31 | 7.45 | 8.62 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL139095 | — | — | 1 | 8.62 |
| CHEMBL285063 | — | — | 1 | 8.57 |
| CHEMBL136511 | — | — | 1 | 8.57 |
| CHEMBL51659 | — | — | 1 | 8.47 |
| CHEMBL545315 | CANERTINIB DIHYDROCHLORIDE | 3.0 | 1 | 8.13 |
| CHEMBL136404 | — | — | 1 | 8.11 |
| CHEMBL136058 | — | — | 1 | 8.06 |
| CHEMBL93464 | — | — | 1 | 8.06 |
| CHEMBL342828 | — | — | 1 | 7.85 |
| CHEMBL138940 | — | — | 1 | 7.85 |
| CHEMBL92086 | — | — | 1 | 7.80 |
| CHEMBL344177 | — | — | 1 | 7.70 |
| CHEMBL434827 | — | — | 1 | 7.68 |
| CHEMBL139044 | — | — | 1 | 7.57 |
| CHEMBL135142 | — | — | 1 | 7.46 |
| CHEMBL138363 | — | — | 1 | 7.36 |
| CHEMBL422292 | — | — | 1 | 7.29 |
| CHEMBL334801 | — | — | 1 | 7.24 |
| CHEMBL345109 | — | — | 1 | 7.23 |
| CHEMBL344486 | — | — | 1 | 7.19 |
| CHEMBL434828 | — | — | 1 | 7.11 |
| CHEMBL140561 | — | — | 1 | 6.97 |
| CHEMBL343722 | — | — | 1 | 6.92 |
| CHEMBL137082 | — | — | 1 | 6.81 |
| CHEMBL136102 | — | — | 1 | 6.71 |
| CHEMBL139307 | — | — | 1 | 6.71 |
| CHEMBL345077 | — | — | 1 | 6.47 |
| CHEMBL136178 | — | — | 1 | 5.98 |
| CHEMBL138691 | — | — | 1 | 5.64 |
| CHEMBL336264 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL139095 | — | IC50 | = | 2.4 | nM | 8.62 |
| CHEMBL285063 | — | IC50 | = | 2.7 | nM | 8.57 |
| CHEMBL136511 | — | IC50 | = | 2.7 | nM | 8.57 |
| CHEMBL51659 | — | IC50 | = | 3.4 | nM | 8.47 |
| CHEMBL545315 | CANERTINIB DIHYDROCHLORIDE | IC50 | = | 7.4 | nM | 8.13 |
| CHEMBL136404 | — | IC50 | = | 7.7 | nM | 8.11 |
| CHEMBL136058 | — | IC50 | = | 8.8 | nM | 8.06 |
| CHEMBL93464 | — | IC50 | = | 8.7 | nM | 8.06 |
| CHEMBL342828 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL138940 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL92086 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL344177 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL434827 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL139044 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL135142 | — | IC50 | = | 35.0 | nM | 7.46 |
| CHEMBL138363 | — | IC50 | = | 44.0 | nM | 7.36 |
| CHEMBL422292 | — | IC50 | = | 51.0 | nM | 7.29 |
| CHEMBL334801 | — | IC50 | = | 57.0 | nM | 7.24 |
| CHEMBL345109 | — | IC50 | = | 59.0 | nM | 7.23 |
| CHEMBL344486 | — | IC50 | = | 64.0 | nM | 7.19 |
| CHEMBL434828 | — | IC50 | = | 77.0 | nM | 7.11 |
| CHEMBL140561 | — | IC50 | = | 108.0 | nM | 6.97 |
| CHEMBL343722 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL137082 | — | IC50 | = | 156.0 | nM | 6.81 |
| CHEMBL136102 | — | IC50 | = | 193.0 | nM | 6.71 |
| CHEMBL139307 | — | IC50 | = | 194.0 | nM | 6.71 |
| CHEMBL345077 | — | IC50 | = | 340.0 | nM | 6.47 |
| CHEMBL136178 | — | IC50 | = | 1039.0 | nM | 5.98 |
| CHEMBL138691 | — | IC50 | = | 2282.0 | nM | 5.64 |
| CHEMBL336264 | — | IC50 | > | 500.0 | nM | - |
| CHEMBL134371 | — | IC50 | > | 500.0 | nM | - |