Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL677221

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Binding affinity for estrogen receptor beta
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Expert

Target

Estrogen receptor beta (CHEMBL242)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Tetrahydroquinoline-based selective estrogen receptor modulators (SERMs).
Wallace OB, Lauwers KS, Jones SA, Dodge JA.
Bioorg Med Chem Lett (2003) 13 : 1907 -1910
PubMed 12749895 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 13 8.06 9.30

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL2137046 1 9.30
CHEMBL56390 1 8.49
CHEMBL60538 1 8.40
CHEMBL81 RALOXIFENE 4.0 1 8.37
CHEMBL56198 1 8.36
CHEMBL56306 1 8.31
CHEMBL58688 1 8.26
CHEMBL293297 1 8.10
CHEMBL59438 1 7.46
CHEMBL293599 1 7.19
CHEMBL59146 1 6.42
CHEMBL56166 1 -
CHEMBL59311 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL2137046 Ki = 0.5 nM 9.30
CHEMBL56390 Ki = 3.2 nM 8.49
CHEMBL60538 Ki = 4.0 nM 8.40
CHEMBL81 RALOXIFENE Ki = 4.3 nM 8.37
CHEMBL56198 Ki = 4.4 nM 8.36
CHEMBL56306 Ki = 4.9 nM 8.31
CHEMBL58688 Ki = 5.5 nM 8.26
CHEMBL293297 Ki = 8.0 nM 8.10
CHEMBL59438 Ki = 35.0 nM 7.46
CHEMBL293599 Ki = 65.0 nM 7.19
CHEMBL59146 Ki = 380.0 nM 6.42
CHEMBL56166 Ki > 1000.0 nM -
CHEMBL59311 Ki > 1000.0 nM -