Assay Detail
Binding
CHEMBL677223
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Inhibition of binding of 17 beta-estradiol to human Estrogen receptor beta
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Phytoestrogens from the roots of Polygonum cuspidatum (Polygonaceae): structure-requirement of hydroxyanthraquinones for estrogenic activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 5 | 6.17 | 7.62 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL44 | GENISTEIN | 2.0 | 1 | 7.62 |
| CHEMBL8145 | DAIDZEIN | 2.0 | 1 | 6.52 |
| CHEMBL298398 | ANTHRAFLAVICACID | — | 1 | 6.16 |
| CHEMBL289277 | EMODIN | — | 1 | 5.82 |
| CHEMBL464360 | EMODIN 8-O-BETA-D-GLUCOPYRANOSIDE | — | 1 | 4.75 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL44 | GENISTEIN | Ki | = | 24.0 | nM | 7.62 |
| CHEMBL8145 | DAIDZEIN | Ki | = | 300.0 | nM | 6.52 |
| CHEMBL298398 | ANTHRAFLAVICACID | Ki | = | 690.0 | nM | 6.16 |
| CHEMBL289277 | EMODIN | Ki | = | 1500.0 | nM | 5.82 |
| CHEMBL464360 | EMODIN 8-O-BETA-D-GLUCOPYRANOSIDE | Ki | = | 18000.0 | nM | 4.75 |