Assay Detail
Binding
CHEMBL677307
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Compound was tested for binding affinity against Endothelin A receptor
26
Total Activities
26
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Thiophenesulfonamides as endothelin receptor antagonists
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 26 | 6.36 | 7.79 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL80857 | — | — | 1 | 7.79 |
| CHEMBL316012 | — | — | 1 | 7.37 |
| CHEMBL432815 | — | — | 1 | 7.32 |
| CHEMBL328517 | — | — | 1 | 7.08 |
| CHEMBL329890 | — | — | 1 | 7.06 |
| CHEMBL89688 | — | — | 1 | 7.00 |
| CHEMBL313801 | — | — | 1 | 6.94 |
| CHEMBL329560 | — | — | 1 | 6.80 |
| CHEMBL89203 | — | — | 1 | 6.74 |
| CHEMBL314307 | — | — | 1 | 6.74 |
| CHEMBL330674 | — | — | 1 | 6.66 |
| CHEMBL313551 | — | — | 1 | 6.51 |
| CHEMBL91073 | — | — | 1 | 6.50 |
| CHEMBL89689 | — | — | 1 | 6.48 |
| CHEMBL293232 | — | — | 1 | 6.22 |
| CHEMBL88506 | — | — | 1 | 6.09 |
| CHEMBL328089 | — | — | 1 | 6.08 |
| CHEMBL329861 | — | — | 1 | 5.88 |
| CHEMBL89457 | — | — | 1 | 5.84 |
| CHEMBL330003 | — | — | 1 | 5.77 |
| CHEMBL91470 | — | — | 1 | 5.72 |
| CHEMBL78080 | — | — | 1 | 5.60 |
| CHEMBL92318 | — | — | 1 | 5.58 |
| CHEMBL265290 | — | — | 1 | 5.56 |
| CHEMBL329375 | — | — | 1 | 5.47 |
| CHEMBL314320 | — | — | 1 | 4.44 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL80857 | — | IC50 | = | 16.2 | nM | 7.79 |
| CHEMBL316012 | — | IC50 | = | 42.85 | nM | 7.37 |
| CHEMBL432815 | — | IC50 | = | 47.9 | nM | 7.32 |
| CHEMBL328517 | — | IC50 | = | 82.3 | nM | 7.08 |
| CHEMBL329890 | — | IC50 | = | 87.3 | nM | 7.06 |
| CHEMBL89688 | — | IC50 | = | 100.2 | nM | 7.00 |
| CHEMBL313801 | — | IC50 | = | 115.0 | nM | 6.94 |
| CHEMBL329560 | — | IC50 | = | 159.6 | nM | 6.80 |
| CHEMBL89203 | — | IC50 | = | 184.0 | nM | 6.74 |
| CHEMBL314307 | — | IC50 | = | 182.0 | nM | 6.74 |
| CHEMBL330674 | — | IC50 | = | 217.5 | nM | 6.66 |
| CHEMBL313551 | — | IC50 | = | 306.0 | nM | 6.51 |
| CHEMBL91073 | — | IC50 | = | 315.5 | nM | 6.50 |
| CHEMBL89689 | — | IC50 | = | 334.0 | nM | 6.48 |
| CHEMBL293232 | — | IC50 | = | 603.0 | nM | 6.22 |
| CHEMBL88506 | — | IC50 | = | 819.0 | nM | 6.09 |
| CHEMBL328089 | — | IC50 | = | 832.0 | nM | 6.08 |
| CHEMBL329861 | — | IC50 | = | 1320.0 | nM | 5.88 |
| CHEMBL89457 | — | IC50 | = | 1450.0 | nM | 5.84 |
| CHEMBL330003 | — | IC50 | = | 1710.0 | nM | 5.77 |
| CHEMBL91470 | — | IC50 | = | 1910.0 | nM | 5.72 |
| CHEMBL78080 | — | IC50 | = | 2510.0 | nM | 5.60 |
| CHEMBL92318 | — | IC50 | = | 2603.0 | nM | 5.58 |
| CHEMBL265290 | — | IC50 | = | 2750.0 | nM | 5.56 |
| CHEMBL329375 | — | IC50 | = | 3390.0 | nM | 5.47 |
| CHEMBL314320 | — | IC50 | = | 36600.0 | nM | 4.44 |