Assay Detail
Functional
CHEMBL677316
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Concentration for 50% inhibition of activity of rat kidney enkephalinase
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Tissue | Feces |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
1H NMR configurational correlation for retro-inverso dipeptides: application to the determination of the absolute configuration of "enkephalinase" inhibitors. Relationships between stereochemistry and enzyme recognition.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 8.80 | 9.39 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL165980 | — | — | 1 | 9.39 |
| CHEMBL51715 | — | — | 1 | 9.32 |
| CHEMBL165922 | — | — | 1 | 9.27 |
| CHEMBL165499 | — | — | 1 | 9.19 |
| CHEMBL164955 | — | — | 1 | 9.12 |
| CHEMBL165744 | — | — | 1 | 8.82 |
| CHEMBL61512 | (R)-THIORPHAN | — | 1 | 8.80 |
| CHEMBL298827 | (S)-THIORPHAN | — | 1 | 8.72 |
| CHEMBL349404 | — | — | 1 | 8.64 |
| CHEMBL45412 | — | — | 1 | 6.68 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL165980 | — | IC50 | = | 0.41 | nM | 9.39 |
| CHEMBL51715 | — | IC50 | = | 0.48 | nM | 9.32 |
| CHEMBL165922 | — | IC50 | = | 0.54 | nM | 9.27 |
| CHEMBL165499 | — | IC50 | = | 0.65 | nM | 9.19 |
| CHEMBL164955 | — | IC50 | = | 0.75 | nM | 9.12 |
| CHEMBL165744 | — | IC50 | = | 1.5 | nM | 8.82 |
| CHEMBL61512 | (R)-THIORPHAN | IC50 | = | 1.6 | nM | 8.80 |
| CHEMBL298827 | (S)-THIORPHAN | IC50 | = | 1.9 | nM | 8.72 |
| CHEMBL349404 | — | IC50 | = | 2.3 | nM | 8.64 |
| CHEMBL45412 | — | IC50 | = | 210.0 | nM | 6.68 |