Assay Detail
Binding
CHEMBL677322
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50% inhibitory activity against enkephalinase purified from rat kidney with [3H]D-Ala2-Leu-enkephalin (20 nM) as substrate.
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
New bidentates as full inhibitors of enkephalin-degrading enzymes: synthesis and analgesic properties.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 2 | 8.76 | 8.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL85320 | KELATORPHAN | — | 1 | 8.77 |
| CHEMBL2079630 | — | — | 1 | 8.74 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL85320 | KELATORPHAN | Ki | = | 1.7 | nM | 8.77 |
| CHEMBL2079630 | — | Ki | = | 1.8 | nM | 8.74 |