Assay Detail
Binding
CHEMBL677323
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Binding affinity towards enkephalinase (metalloendopeptidase, E.C.3.4.24.11) of human
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Synthesis and biological evaluation of phosphonamidate peptide inhibitors of enkephalinase and angiotensin-converting enzyme.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 3 | 6.63 | 6.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL19352 | — | — | 1 | 6.96 |
| CHEMBL429227 | — | — | 1 | 6.55 |
| CHEMBL277431 | — | — | 1 | 6.38 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL19352 | — | Ki | = | 110.0 | nM | 6.96 |
| CHEMBL429227 | — | Ki | = | 280.0 | nM | 6.55 |
| CHEMBL277431 | — | Ki | = | 420.0 | nM | 6.38 |