Assay Detail
Binding
CHEMBL677367
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Binding affinity towards dopamine transporter using [3H]WIN-35428 as radioligand in rat caudate-putamen tissue
8
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Caudate-putamen |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Sodium-dependent dopamine transporter (CHEMBL338) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Synthesis and dopamine transporter affinity of the four stereoisomers of (+/-)-2-(methoxycarbonyl)-7-methyl-3-phenyl-7-azabicyclo[2.2.1]heptane.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 8 | 5.76 | 7.50 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL370805 | COCAINE | 4.0 | 2 | 7.50 |
| CHEMBL1790051 | — | — | 2 | 7.48 |
| CHEMBL414881 | — | — | 1 | 5.25 |
| CHEMBL78985 | — | — | 1 | 4.72 |
| CHEMBL81329 | — | — | 1 | 4.22 |
| CHEMBL545473 | — | — | 1 | 4.01 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL370805 | COCAINE | Ki | = | 32.0 | nM | 7.50 |
| CHEMBL1790051 | — | Ki | = | 33.0 | nM | 7.48 |
| CHEMBL1790051 | — | Ki | = | 310.0 | nM | 6.51 |
| CHEMBL370805 | COCAINE | Ki | = | 390.0 | nM | 6.41 |
| CHEMBL414881 | — | Ki | = | 5620.0 | nM | 5.25 |
| CHEMBL78985 | — | Ki | = | 18900.0 | nM | 4.72 |
| CHEMBL81329 | — | Ki | = | 60400.0 | nM | 4.22 |
| CHEMBL545473 | — | Ki | = | 96500.0 | nM | 4.01 |