Assay Detail
Binding
CHEMBL677369
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Binding affinity towards dopamine transporter using [3H]-mazindol as radioligand in rat striatal membranes.
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Sodium-dependent dopamine transporter (CHEMBL338) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Chemistry and biology of the 2 beta-alkyl-3 beta-phenyl analogues of cocaine: subnanomolar affinity ligands that suggest a new pharmacophore model at the C-2 position.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 12 | 8.98 | 9.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL320427 | — | — | 1 | 9.85 |
| CHEMBL107808 | — | — | 1 | 9.66 |
| CHEMBL106627 | — | — | 1 | 9.51 |
| CHEMBL28394 | — | — | 1 | 9.38 |
| CHEMBL281288 | — | — | 1 | 9.23 |
| CHEMBL610897 | — | — | 1 | 9.08 |
| CHEMBL321888 | — | — | 1 | 9.03 |
| CHEMBL432401 | — | — | 1 | 8.92 |
| CHEMBL104567 | — | — | 1 | 8.84 |
| CHEMBL420291 | — | — | 1 | 8.73 |
| CHEMBL27336 | — | — | 1 | 8.66 |
| CHEMBL322365 | — | — | 1 | 6.81 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL320427 | — | Ki | = | 0.14 | nM | 9.85 |
| CHEMBL107808 | — | Ki | = | 0.22 | nM | 9.66 |
| CHEMBL106627 | — | Ki | = | 0.31 | nM | 9.51 |
| CHEMBL28394 | — | Ki | = | 0.42 | nM | 9.38 |
| CHEMBL281288 | — | Ki | = | 0.59 | nM | 9.23 |
| CHEMBL610897 | — | Ki | = | 0.83 | nM | 9.08 |
| CHEMBL321888 | — | Ki | = | 0.94 | nM | 9.03 |
| CHEMBL432401 | — | Ki | = | 1.21 | nM | 8.92 |
| CHEMBL104567 | — | Ki | = | 1.46 | nM | 8.84 |
| CHEMBL420291 | — | Ki | = | 1.87 | nM | 8.73 |
| CHEMBL27336 | — | Ki | = | 2.17 | nM | 8.66 |
| CHEMBL322365 | — | Ki | = | 155.7 | nM | 6.81 |