Assay Detail
Binding
CHEMBL677370
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity for dopamine transporter
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Sodium-dependent dopamine transporter (CHEMBL338) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Development of long-acting dopamine transporter ligands as potential cocaine-abuse therapeutic agents: chiral hydroxyl-containing derivatives of 1-[2-[bis(4-fluorophenyl)methoxy]ethyl]-4-(3-phenylpropyl)piperazine and 1-[2-(diphenylmethoxy)ethyl]-4-(3-phenylpropyl)piperazine.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 17 | 8.03 | 9.12 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL27646 | — | — | 1 | 9.12 |
| CHEMBL417660 | — | — | 1 | 8.68 |
| CHEMBL27826 | — | — | 1 | 8.64 |
| CHEMBL28149 | — | — | 1 | 8.64 |
| CHEMBL26477 | — | — | 1 | 8.52 |
| CHEMBL26320 | — | — | 1 | 8.43 |
| CHEMBL281594 | VANOXERINE | 3.0 | 1 | 8.43 |
| CHEMBL26478 | — | — | 1 | 8.36 |
| CHEMBL26649 | — | — | 1 | 8.10 |
| CHEMBL279461 | — | — | 1 | 7.96 |
| CHEMBL27490 | — | — | 1 | 7.92 |
| CHEMBL282380 | — | — | 1 | 7.60 |
| CHEMBL278616 | — | — | 1 | 7.58 |
| CHEMBL26013 | — | — | 1 | 7.52 |
| CHEMBL416194 | — | — | 1 | 7.32 |
| CHEMBL283473 | — | — | 1 | 6.92 |
| CHEMBL283869 | — | — | 1 | 6.77 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL27646 | — | Ki | = | 0.75 | nM | 9.12 |
| CHEMBL417660 | — | Ki | = | 2.1 | nM | 8.68 |
| CHEMBL27826 | — | Ki | = | 2.3 | nM | 8.64 |
| CHEMBL28149 | — | Ki | = | 2.3 | nM | 8.64 |
| CHEMBL26477 | — | Ki | = | 3.0 | nM | 8.52 |
| CHEMBL26320 | — | Ki | = | 3.7 | nM | 8.43 |
| CHEMBL281594 | VANOXERINE | Ki | = | 3.7 | nM | 8.43 |
| CHEMBL26478 | — | Ki | = | 4.4 | nM | 8.36 |
| CHEMBL26649 | — | Ki | = | 8.0 | nM | 8.10 |
| CHEMBL279461 | — | Ki | = | 11.0 | nM | 7.96 |
| CHEMBL27490 | — | Ki | = | 12.0 | nM | 7.92 |
| CHEMBL282380 | — | Ki | = | 25.0 | nM | 7.60 |
| CHEMBL278616 | — | Ki | = | 26.0 | nM | 7.58 |
| CHEMBL26013 | — | Ki | = | 30.0 | nM | 7.52 |
| CHEMBL416194 | — | Ki | = | 48.0 | nM | 7.32 |
| CHEMBL283473 | — | Ki | = | 120.0 | nM | 6.92 |
| CHEMBL283869 | — | Ki | = | 170.0 | nM | 6.77 |