Assay Detail
Binding
CHEMBL677371
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Binding affinity to dopamine transporter (DAT) in rat forebrain tissue
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Forebrain |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Sodium-dependent dopamine transporter (CHEMBL338) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Synthesis and monoamine transporter affinity of 3'-analogs of 2-beta-carbomethoxy-3-beta-(4'-iodophenyl)tropane (beta-CIT).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 7 | 7.98 | 9.19 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL14613 | — | — | 1 | 9.19 |
| CHEMBL311347 | — | — | 1 | 8.88 |
| CHEMBL294733 | — | — | 1 | 8.02 |
| CHEMBL66068 | — | — | 1 | 7.67 |
| CHEMBL303232 | — | — | 1 | 7.62 |
| CHEMBL303494 | — | — | 1 | 7.51 |
| CHEMBL67387 | — | — | 1 | 7.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL14613 | — | Ki | = | 0.64 | nM | 9.19 |
| CHEMBL311347 | — | Ki | = | 1.33 | nM | 8.88 |
| CHEMBL294733 | — | Ki | = | 9.59 | nM | 8.02 |
| CHEMBL66068 | — | Ki | = | 21.2 | nM | 7.67 |
| CHEMBL303232 | — | Ki | = | 23.7 | nM | 7.62 |
| CHEMBL303494 | — | Ki | = | 30.8 | nM | 7.51 |
| CHEMBL67387 | — | Ki | = | 100.0 | nM | 7.00 |