Assay Detail
Binding
CHEMBL677375
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Displacement of [3H]GBR-12935 from rat forebrain Dopamine transporter
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Sodium-dependent dopamine transporter (CHEMBL338) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Synthesis and monoamine transporter affinity of 2beta-carbomethoxy-3beta-(2''-, 3''- or 4''-substituted) biphenyltropanes.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 12 | 7.63 | 9.02 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL311347 | — | — | 1 | 9.02 |
| CHEMBL300511 | — | — | 1 | 8.29 |
| CHEMBL301174 | — | — | 1 | 8.02 |
| CHEMBL52334 | — | — | 1 | 7.91 |
| CHEMBL296394 | — | — | 1 | 7.88 |
| CHEMBL51896 | — | — | 1 | 7.82 |
| CHEMBL50997 | — | — | 1 | 7.72 |
| CHEMBL50674 | — | — | 1 | 7.62 |
| CHEMBL51454 | — | — | 1 | 7.23 |
| CHEMBL299635 | — | — | 1 | 6.45 |
| CHEMBL50886 | — | — | 1 | 5.99 |
| CHEMBL50675 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL311347 | — | Ki | = | 0.96 | nM | 9.02 |
| CHEMBL300511 | — | Ki | = | 5.1 | nM | 8.29 |
| CHEMBL301174 | — | Ki | = | 9.54 | nM | 8.02 |
| CHEMBL52334 | — | Ki | = | 12.4 | nM | 7.91 |
| CHEMBL296394 | — | Ki | = | 13.2 | nM | 7.88 |
| CHEMBL51896 | — | Ki | = | 15.2 | nM | 7.82 |
| CHEMBL50997 | — | Ki | = | 19.1 | nM | 7.72 |
| CHEMBL50674 | — | Ki | = | 24.2 | nM | 7.62 |
| CHEMBL51454 | — | Ki | = | 58.7 | nM | 7.23 |
| CHEMBL299635 | — | Ki | = | 357.0 | nM | 6.45 |
| CHEMBL50886 | — | Ki | = | 1016.0 | nM | 5.99 |
| CHEMBL50675 | — | Ki | > | 3000.0 | nM | - |