Assay Detail
Binding
CHEMBL677384
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Inhibition of epidermal growth factor receptor kinase autophosphorylation
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Syntheses and EGFR kinase inhibitory activity of 6-substituted-4-anilino [1,7] and [1,8] naphthyridine-3-carbonitriles.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 6.45 | 8.07 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL31276 | — | — | 1 | 8.07 |
| CHEMBL281300 | — | — | 1 | 7.06 |
| CHEMBL607707 | PELITINIB | 2.0 | 1 | 7.01 |
| CHEMBL30973 | — | — | 1 | 6.91 |
| CHEMBL281467 | — | — | 1 | 6.01 |
| CHEMBL31876 | — | — | 1 | 5.99 |
| CHEMBL441518 | — | — | 1 | 5.38 |
| CHEMBL287022 | — | — | 1 | 5.17 |
| CHEMBL31745 | — | — | 1 | - |
| CHEMBL283682 | — | — | 1 | - |
| CHEMBL31437 | — | — | 1 | - |
| CHEMBL31118 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL31276 | — | IC50 | = | 8.6 | nM | 8.07 |
| CHEMBL281300 | — | IC50 | = | 86.9 | nM | 7.06 |
| CHEMBL607707 | PELITINIB | IC50 | = | 97.6 | nM | 7.01 |
| CHEMBL30973 | — | IC50 | = | 122.9 | nM | 6.91 |
| CHEMBL281467 | — | IC50 | = | 975.7 | nM | 6.01 |
| CHEMBL31876 | — | IC50 | = | 1027.8 | nM | 5.99 |
| CHEMBL441518 | — | IC50 | = | 4128.6 | nM | 5.38 |
| CHEMBL287022 | — | IC50 | = | 6794.8 | nM | 5.17 |
| CHEMBL31745 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL283682 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL31437 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL31118 | — | IC50 | > | 10000.0 | nM | - |