Assay Detail
Binding
CHEMBL677386
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Inhibition of epidermal growth factor receptor (EGFR) from human A431 carcinoma cells
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | A-431 |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Tyrosine kinase inhibitors. 13. Structure-activity relationships for soluble 7-substituted 4-[(3-bromophenyl)amino]pyrido[4,3-d]pyrimidines designed as inhibitors of the tyrosine kinase activity of the epidermal growth factor receptor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 8.73 | 9.29 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL126791 | — | — | 1 | 9.29 |
| CHEMBL338114 | — | — | 1 | 9.04 |
| CHEMBL340898 | — | — | 1 | 8.46 |
| CHEMBL340399 | — | — | 1 | 8.14 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL126791 | — | IC50 | = | 0.51 | nM | 9.29 |
| CHEMBL338114 | — | IC50 | = | 0.91 | nM | 9.04 |
| CHEMBL340898 | — | IC50 | = | 3.5 | nM | 8.46 |
| CHEMBL340399 | — | IC50 | = | 7.2 | nM | 8.14 |