Assay Detail
Binding
CHEMBL677387
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Inhibition of phosphorylation of polyglutamic acid/tyrosine random copolymer by epidermal growth factor receptor.
35
Total Activities
35
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Tyrosine kinase inhibitors. 13. Structure-activity relationships for soluble 7-substituted 4-[(3-bromophenyl)amino]pyrido[4,3-d]pyrimidines designed as inhibitors of the tyrosine kinase activity of the epidermal growth factor receptor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 35 | 8.55 | 10.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL53428 | — | — | 1 | 10.05 |
| CHEMBL420624 | — | — | 1 | 10.00 |
| CHEMBL54400 | — | — | 1 | 9.89 |
| CHEMBL127041 | — | — | 1 | 9.62 |
| CHEMBL128468 | — | — | 1 | 9.55 |
| CHEMBL127086 | — | — | 1 | 9.21 |
| CHEMBL339416 | — | — | 1 | 9.13 |
| CHEMBL126372 | — | — | 1 | 9.04 |
| CHEMBL127058 | — | — | 1 | 8.92 |
| CHEMBL127082 | — | — | 1 | 8.85 |
| CHEMBL128467 | — | — | 1 | 8.85 |
| CHEMBL338175 | — | — | 1 | 8.82 |
| CHEMBL126623 | — | — | 1 | 8.72 |
| CHEMBL341319 | — | — | 1 | 8.59 |
| CHEMBL127611 | — | — | 1 | 8.49 |
| CHEMBL128987 | — | — | 1 | 8.49 |
| CHEMBL340700 | — | — | 1 | 8.49 |
| CHEMBL92812 | — | — | 1 | 8.40 |
| CHEMBL129579 | — | — | 1 | 8.32 |
| CHEMBL340484 | — | — | 1 | 8.31 |
| CHEMBL126384 | — | — | 1 | 8.27 |
| CHEMBL338215 | — | — | 1 | 8.27 |
| CHEMBL341522 | — | — | 1 | 8.25 |
| CHEMBL340508 | — | — | 1 | 8.15 |
| CHEMBL129825 | — | — | 1 | 8.13 |
| CHEMBL129824 | — | — | 1 | 8.08 |
| CHEMBL126893 | — | — | 1 | 8.06 |
| CHEMBL435993 | — | — | 1 | 8.04 |
| CHEMBL129509 | — | — | 1 | 8.03 |
| CHEMBL52076 | — | — | 1 | 8.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL53428 | — | IC50 | = | 0.09 | nM | 10.05 |
| CHEMBL420624 | — | IC50 | = | 0.1 | nM | 10.00 |
| CHEMBL54400 | — | IC50 | = | 0.13 | nM | 9.89 |
| CHEMBL127041 | — | IC50 | = | 0.24 | nM | 9.62 |
| CHEMBL128468 | — | IC50 | = | 0.28 | nM | 9.55 |
| CHEMBL127086 | — | IC50 | = | 0.61 | nM | 9.21 |
| CHEMBL339416 | — | IC50 | = | 0.74 | nM | 9.13 |
| CHEMBL126372 | — | IC50 | = | 0.92 | nM | 9.04 |
| CHEMBL127058 | — | IC50 | = | 1.2 | nM | 8.92 |
| CHEMBL127082 | — | IC50 | = | 1.4 | nM | 8.85 |
| CHEMBL128467 | — | IC50 | = | 1.4 | nM | 8.85 |
| CHEMBL338175 | — | IC50 | = | 1.5 | nM | 8.82 |
| CHEMBL126623 | — | IC50 | = | 1.9 | nM | 8.72 |
| CHEMBL341319 | — | IC50 | = | 2.6 | nM | 8.59 |
| CHEMBL340700 | — | IC50 | = | 3.2 | nM | 8.49 |
| CHEMBL127611 | — | IC50 | = | 3.2 | nM | 8.49 |
| CHEMBL128987 | — | IC50 | = | 3.2 | nM | 8.49 |
| CHEMBL92812 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL129579 | — | IC50 | = | 4.8 | nM | 8.32 |
| CHEMBL340484 | — | IC50 | = | 4.9 | nM | 8.31 |
| CHEMBL126384 | — | IC50 | = | 5.4 | nM | 8.27 |
| CHEMBL338215 | — | IC50 | = | 5.4 | nM | 8.27 |
| CHEMBL341522 | — | IC50 | = | 5.6 | nM | 8.25 |
| CHEMBL340508 | — | IC50 | = | 7.1 | nM | 8.15 |
| CHEMBL129825 | — | IC50 | = | 7.4 | nM | 8.13 |
| CHEMBL129824 | — | IC50 | = | 8.4 | nM | 8.08 |
| CHEMBL126893 | — | IC50 | = | 8.8 | nM | 8.06 |
| CHEMBL435993 | — | IC50 | = | 9.2 | nM | 8.04 |
| CHEMBL129509 | — | IC50 | = | 9.3 | nM | 8.03 |
| CHEMBL52076 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL128759 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL125568 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL126903 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL126137 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL128432 | — | IC50 | = | 45.0 | nM | 7.35 |