Assay Detail
Binding
CHEMBL677391
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Inhibition of tyrosine phosphorylation activity of the epidermal growth factor receptor (EGFR) tyrosine kinase from human A-431 carcinoma cell-shed membrane vesicles
33
Total Activities
33
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Tyrosine kinase inhibitors. 3. Structure-activity relationships for inhibition of protein tyrosine kinases by nuclear-substituted derivatives of 2,2'-dithiobis(1-methyl-N-phenyl-1H-indole-3-carboxamide).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 33 | 4.87 | 6.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL62176 | — | — | 1 | 6.00 |
| CHEMBL60472 | — | — | 1 | 5.44 |
| CHEMBL293889 | — | — | 1 | 5.37 |
| CHEMBL64430 | — | — | 1 | 5.30 |
| CHEMBL61119 | — | — | 1 | 5.28 |
| CHEMBL292323 | — | — | 1 | 5.19 |
| CHEMBL291359 | — | — | 1 | 5.00 |
| CHEMBL304414 | — | — | 1 | 5.00 |
| CHEMBL293251 | — | — | 1 | 4.94 |
| CHEMBL59812 | — | — | 1 | 4.70 |
| CHEMBL62701 | — | — | 1 | 4.65 |
| CHEMBL293250 | — | — | 1 | 4.39 |
| CHEMBL293913 | — | — | 1 | 4.36 |
| CHEMBL291979 | — | — | 1 | 4.27 |
| CHEMBL62843 | — | — | 1 | 4.00 |
| CHEMBL293986 | — | — | 1 | 4.00 |
| CHEMBL303127 | — | — | 1 | - |
| CHEMBL291667 | — | — | 1 | - |
| CHEMBL64459 | — | — | 1 | - |
| CHEMBL294341 | — | — | 1 | - |
| CHEMBL63009 | — | — | 1 | - |
| CHEMBL64781 | — | — | 1 | - |
| CHEMBL61278 | — | — | 1 | - |
| CHEMBL292287 | — | — | 1 | - |
| CHEMBL60200 | — | — | 1 | - |
| CHEMBL64068 | — | — | 1 | - |
| CHEMBL62067 | — | — | 1 | - |
| CHEMBL63455 | — | — | 1 | - |
| CHEMBL64814 | — | — | 1 | - |
| CHEMBL64165 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL62176 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL60472 | — | IC50 | = | 3600.0 | nM | 5.44 |
| CHEMBL293889 | — | IC50 | = | 4300.0 | nM | 5.37 |
| CHEMBL64430 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL61119 | — | IC50 | = | 5300.0 | nM | 5.28 |
| CHEMBL292323 | — | IC50 | = | 6500.0 | nM | 5.19 |
| CHEMBL291359 | — | IC50 | = | 9900.0 | nM | 5.00 |
| CHEMBL304414 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL293251 | — | IC50 | = | 11400.0 | nM | 4.94 |
| CHEMBL59812 | — | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL62701 | — | IC50 | = | 22300.0 | nM | 4.65 |
| CHEMBL293250 | — | IC50 | = | 40500.0 | nM | 4.39 |
| CHEMBL293913 | — | IC50 | = | 44000.0 | nM | 4.36 |
| CHEMBL291979 | — | IC50 | = | 54100.0 | nM | 4.27 |
| CHEMBL293986 | — | IC50 | = | 100000.0 | nM | 4.00 |
| CHEMBL62843 | — | IC50 | = | 100000.0 | nM | 4.00 |
| CHEMBL64231 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL62699 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL294205 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL64165 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL64814 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL63455 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL62067 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL64068 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL60200 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL292287 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL61278 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL64781 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL63009 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL294341 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL64459 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL291667 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL303127 | — | IC50 | > | 100000.0 | nM | - |