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Assay Detail

CHEMBL677392

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Binding
Inhibitory concentration against EGF receptor by polyGAT phosphorylation
25
Total Activities
25
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 8 — Homologous single protein target
Curated By Expert

Target

Epidermal growth factor receptor (CHEMBL203)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Tyrphostins. 3. Structure-activity relationship studies of alpha-substituted benzylidenemalononitrile 5-S-aryltyrphostins.
Gazit A, Osherov N, Posner I, Bar-Sinai A, Gilon C, Levitzki A.
J Med Chem (1993) 36 : 3556 -3564
PubMed 7902440 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 25 5.00 6.12

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL116547 1 6.12
CHEMBL432428 1 6.03
CHEMBL326318 1 5.71
CHEMBL419047 1 5.60
CHEMBL326100 1 5.60
CHEMBL116595 1 5.54
CHEMBL115519 1 5.36
CHEMBL115895 1 5.25
CHEMBL116423 1 5.25
CHEMBL333553 1 5.19
CHEMBL330879 1 5.18
CHEMBL333454 1 5.06
CHEMBL118205 1 4.90
CHEMBL119923 1 4.83
CHEMBL324030 1 4.79
CHEMBL118109 1 4.73
CHEMBL119156 1 4.60
CHEMBL118321 1 4.44
CHEMBL119987 1 4.43
CHEMBL326044 1 4.22
CHEMBL331026 1 4.12
CHEMBL334032 1 4.07
CHEMBL120719 1 4.02
CHEMBL122522 1 -
CHEMBL120564 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL116547 IC50 = 750.0 nM 6.12
CHEMBL432428 IC50 = 940.0 nM 6.03
CHEMBL326318 IC50 = 1950.0 nM 5.71
CHEMBL419047 IC50 = 2500.0 nM 5.60
CHEMBL326100 IC50 = 2500.0 nM 5.60
CHEMBL116595 IC50 = 2900.0 nM 5.54
CHEMBL115519 IC50 = 4400.0 nM 5.36
CHEMBL115895 IC50 = 5600.0 nM 5.25
CHEMBL116423 IC50 = 5600.0 nM 5.25
CHEMBL333553 IC50 = 6500.0 nM 5.19
CHEMBL330879 IC50 = 6600.0 nM 5.18
CHEMBL333454 IC50 = 8700.0 nM 5.06
CHEMBL118205 IC50 = 12500.0 nM 4.90
CHEMBL119923 IC50 = 14800.0 nM 4.83
CHEMBL324030 IC50 = 16300.0 nM 4.79
CHEMBL118109 IC50 = 18600.0 nM 4.73
CHEMBL119156 IC50 = 25000.0 nM 4.60
CHEMBL118321 IC50 = 36000.0 nM 4.44
CHEMBL119987 IC50 = 37000.0 nM 4.43
CHEMBL326044 IC50 = 60000.0 nM 4.22
CHEMBL331026 IC50 = 75000.0 nM 4.12
CHEMBL334032 IC50 = 85000.0 nM 4.07
CHEMBL120719 IC50 = 96000.0 nM 4.02
CHEMBL122522 IC50 = 370000.0 nM -
CHEMBL120564 IC50 = 2600000.0 nM -