Assay Detail
Binding
CHEMBL677393
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Inhibitory concentration against EGF receptor by autophosphorylation
27
Total Activities
27
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Tyrphostins. 3. Structure-activity relationship studies of alpha-substituted benzylidenemalononitrile 5-S-aryltyrphostins.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 27 | 5.22 | 6.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL116595 | — | — | 1 | 6.40 |
| CHEMBL432428 | — | — | 1 | 6.19 |
| CHEMBL119987 | — | — | 1 | 6.15 |
| CHEMBL326318 | — | — | 1 | 6.05 |
| CHEMBL326100 | — | — | 1 | 6.00 |
| CHEMBL330879 | — | — | 1 | 5.77 |
| CHEMBL333454 | — | — | 1 | 5.76 |
| CHEMBL419047 | — | — | 1 | 5.60 |
| CHEMBL333553 | — | — | 1 | 5.50 |
| CHEMBL119156 | — | — | 1 | 5.47 |
| CHEMBL116547 | — | — | 1 | 5.35 |
| CHEMBL118205 | — | — | 1 | 5.28 |
| CHEMBL122522 | — | — | 1 | 5.17 |
| CHEMBL118321 | — | — | 1 | 5.10 |
| CHEMBL324030 | — | — | 1 | 5.06 |
| CHEMBL331026 | — | — | 1 | 4.84 |
| CHEMBL119923 | — | — | 1 | 4.80 |
| CHEMBL118109 | — | — | 1 | 4.72 |
| CHEMBL115895 | — | — | 1 | 4.66 |
| CHEMBL334032 | — | — | 1 | 4.64 |
| CHEMBL326044 | — | — | 1 | 4.32 |
| CHEMBL120719 | — | — | 1 | 4.27 |
| CHEMBL116423 | — | — | 1 | 4.21 |
| CHEMBL120564 | — | — | 1 | 4.06 |
| CHEMBL115519 | — | — | 1 | - |
| CHEMBL117055 | — | — | 1 | - |
| CHEMBL424625 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL116595 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL432428 | — | IC50 | = | 640.0 | nM | 6.19 |
| CHEMBL119987 | — | IC50 | = | 710.0 | nM | 6.15 |
| CHEMBL326318 | — | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL326100 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL330879 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL333454 | — | IC50 | = | 1750.0 | nM | 5.76 |
| CHEMBL419047 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL333553 | — | IC50 | = | 3200.0 | nM | 5.50 |
| CHEMBL119156 | — | IC50 | = | 3400.0 | nM | 5.47 |
| CHEMBL116547 | — | IC50 | = | 4500.0 | nM | 5.35 |
| CHEMBL118205 | — | IC50 | = | 5300.0 | nM | 5.28 |
| CHEMBL122522 | — | IC50 | = | 6700.0 | nM | 5.17 |
| CHEMBL118321 | — | IC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL324030 | — | IC50 | = | 8800.0 | nM | 5.06 |
| CHEMBL331026 | — | IC50 | = | 14500.0 | nM | 4.84 |
| CHEMBL119923 | — | IC50 | = | 16000.0 | nM | 4.80 |
| CHEMBL118109 | — | IC50 | = | 19000.0 | nM | 4.72 |
| CHEMBL115895 | — | IC50 | = | 22000.0 | nM | 4.66 |
| CHEMBL334032 | — | IC50 | = | 23000.0 | nM | 4.64 |
| CHEMBL326044 | — | IC50 | = | 48000.0 | nM | 4.32 |
| CHEMBL120719 | — | IC50 | = | 54000.0 | nM | 4.27 |
| CHEMBL116423 | — | IC50 | = | 62000.0 | nM | 4.21 |
| CHEMBL120564 | — | IC50 | = | 87000.0 | nM | 4.06 |
| CHEMBL115519 | — | IC50 | > | 83000.0 | nM | - |
| CHEMBL117055 | — | IC50 | > | 167000.0 | nM | - |
| CHEMBL424625 | — | IC50 | > | 50000.0 | nM | - |