Assay Detail
Binding
CHEMBL677400
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Inhibition of ET-1 binding to Endothelin B receptor in cultured rat cerebellar membranes
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Subcellular | Membrane |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Design of a functional hexapeptide antagonist of endothelin.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 5.80 | 8.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL437472 | ENDOTHELIN | 2.0 | 1 | 8.80 |
| CHEMBL328942 | — | — | 1 | 6.82 |
| CHEMBL317064 | — | — | 1 | 5.75 |
| CHEMBL86814 | — | — | 1 | 5.48 |
| CHEMBL438194 | — | — | 1 | 5.46 |
| CHEMBL315047 | — | — | 1 | 5.40 |
| CHEMBL85341 | — | — | 1 | 5.16 |
| CHEMBL289687 | — | — | 1 | 5.00 |
| CHEMBL432091 | — | — | 1 | 4.37 |
| CHEMBL34540 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL437472 | ENDOTHELIN | IC50 | = | 1.6 | nM | 8.80 |
| CHEMBL328942 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL317064 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL86814 | — | IC50 | = | 3300.0 | nM | 5.48 |
| CHEMBL438194 | — | IC50 | = | 3500.0 | nM | 5.46 |
| CHEMBL315047 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL85341 | — | IC50 | = | 7000.0 | nM | 5.16 |
| CHEMBL289687 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL432091 | — | IC50 | = | 43000.0 | nM | 4.37 |
| CHEMBL34540 | — | IC50 | > | 50000.0 | nM | - |