Assay Detail
Binding
CHEMBL677407
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Inhibition of [125I]-endothelin-3 [ET-3] binding to endothelin B receptor (ETB) of rat cerebellum
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Cerebellum |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Structure-activity and biophysical studies of the C-terminal hexapeptide of endothelin
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 5.41 | 7.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1791271 | — | — | 1 | 7.22 |
| CHEMBL2369709 | — | — | 1 | 6.57 |
| CHEMBL2369713 | — | — | 1 | 6.11 |
| CHEMBL1791279 | — | — | 1 | 5.70 |
| CHEMBL2369714 | — | — | 1 | 5.18 |
| CHEMBL1791280 | — | — | 1 | 5.08 |
| CHEMBL289687 | — | — | 1 | 5.04 |
| CHEMBL2369710 | — | — | 1 | 4.89 |
| CHEMBL1791277 | — | — | 1 | 4.85 |
| CHEMBL2369711 | — | — | 1 | 4.47 |
| CHEMBL432091 | — | — | 1 | 4.37 |
| CHEMBL34540 | — | — | 1 | - |
| CHEMBL1791272 | — | — | 1 | - |
| CHEMBL2369712 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1791271 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL2369709 | — | IC50 | = | 270.0 | nM | 6.57 |
| CHEMBL2369713 | — | IC50 | = | 780.0 | nM | 6.11 |
| CHEMBL1791279 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL2369714 | — | IC50 | = | 6600.0 | nM | 5.18 |
| CHEMBL1791280 | — | IC50 | = | 8300.0 | nM | 5.08 |
| CHEMBL289687 | — | IC50 | = | 9100.0 | nM | 5.04 |
| CHEMBL2369710 | — | IC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL1791277 | — | IC50 | = | 14000.0 | nM | 4.85 |
| CHEMBL2369711 | — | IC50 | = | 34000.0 | nM | 4.47 |
| CHEMBL432091 | — | IC50 | = | 43000.0 | nM | 4.37 |
| CHEMBL34540 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL1791272 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL2369712 | — | IC50 | > | 50000.0 | nM | - |