Assay Detail
Binding
CHEMBL677470
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibitory concentration compound against EFGR tyrosine kinase obtained from plasma membrane vesicles from cultured A431 cells
39
Total Activities
39
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Plasma |
| Cell Type | A-431 |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Tyrosine kinase inhibitors. 4. Structure-activity relationships among N- and 3-substituted 2,2'-dithiobis(1H-indoles) for in vitro inhibition of receptor and nonreceptor protein tyrosine kinases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 39 | 4.96 | 5.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL158275 | — | — | 1 | 5.77 |
| CHEMBL342929 | — | — | 1 | 5.75 |
| CHEMBL336174 | — | — | 1 | 5.48 |
| CHEMBL79704 | — | — | 1 | 5.38 |
| CHEMBL293889 | — | — | 1 | 5.37 |
| CHEMBL157807 | — | — | 1 | 5.33 |
| CHEMBL158805 | — | — | 1 | 5.28 |
| CHEMBL346770 | — | — | 1 | 5.26 |
| CHEMBL351920 | — | — | 1 | 5.25 |
| CHEMBL161226 | — | — | 1 | 5.21 |
| CHEMBL346553 | — | — | 1 | 5.21 |
| CHEMBL160566 | — | — | 1 | 5.16 |
| CHEMBL160935 | — | — | 1 | 5.11 |
| CHEMBL345211 | — | — | 1 | 5.00 |
| CHEMBL304414 | — | — | 1 | 4.96 |
| CHEMBL345837 | — | — | 1 | 4.92 |
| CHEMBL347659 | — | — | 1 | 4.89 |
| CHEMBL347160 | — | — | 1 | 4.82 |
| CHEMBL347161 | — | — | 1 | 4.77 |
| CHEMBL348554 | — | — | 1 | 4.76 |
| CHEMBL160207 | — | — | 1 | 4.67 |
| CHEMBL347854 | — | — | 1 | 4.54 |
| CHEMBL158797 | — | — | 1 | 4.37 |
| CHEMBL435054 | — | — | 1 | 4.33 |
| CHEMBL345862 | — | — | 1 | 4.33 |
| CHEMBL422540 | — | — | 1 | 4.00 |
| CHEMBL345641 | — | — | 1 | 4.00 |
| CHEMBL348069 | — | — | 1 | - |
| CHEMBL158879 | — | — | 1 | - |
| CHEMBL349762 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL158275 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL342929 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL336174 | — | IC50 | = | 3300.0 | nM | 5.48 |
| CHEMBL79704 | — | IC50 | = | 4200.0 | nM | 5.38 |
| CHEMBL293889 | — | IC50 | = | 4300.0 | nM | 5.37 |
| CHEMBL157807 | — | IC50 | = | 4700.0 | nM | 5.33 |
| CHEMBL158805 | — | IC50 | = | 5300.0 | nM | 5.28 |
| CHEMBL346770 | — | IC50 | = | 5500.0 | nM | 5.26 |
| CHEMBL351920 | — | IC50 | = | 5600.0 | nM | 5.25 |
| CHEMBL161226 | — | IC50 | = | 6100.0 | nM | 5.21 |
| CHEMBL346553 | — | IC50 | = | 6100.0 | nM | 5.21 |
| CHEMBL160566 | — | IC50 | = | 6900.0 | nM | 5.16 |
| CHEMBL160935 | — | IC50 | = | 7700.0 | nM | 5.11 |
| CHEMBL345211 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL304414 | — | IC50 | = | 10900.0 | nM | 4.96 |
| CHEMBL345837 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL347659 | — | IC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL347160 | — | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL347161 | — | IC50 | = | 16900.0 | nM | 4.77 |
| CHEMBL348554 | — | IC50 | = | 17500.0 | nM | 4.76 |
| CHEMBL160207 | — | IC50 | = | 21200.0 | nM | 4.67 |
| CHEMBL347854 | — | IC50 | = | 28700.0 | nM | 4.54 |
| CHEMBL158797 | — | IC50 | = | 43000.0 | nM | 4.37 |
| CHEMBL435054 | — | IC50 | = | 47000.0 | nM | 4.33 |
| CHEMBL345862 | — | IC50 | = | 47000.0 | nM | 4.33 |
| CHEMBL422540 | — | IC50 | = | 100000.0 | nM | 4.00 |
| CHEMBL345641 | — | IC50 | = | 100000.0 | nM | 4.00 |
| CHEMBL352010 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL158596 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL347256 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL345622 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL314029 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL61278 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL156281 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL349322 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL156020 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL349762 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL158879 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL348069 | — | IC50 | > | 100000.0 | nM | - |