Assay Detail
Binding
CHEMBL677478
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Binding affinity for human estrogen receptor alpha
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Estrogen receptor ligands. Part 6: Synthesis and binding affinity of dihydrobenzodithiins.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 8.37 | 9.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL304552 | — | — | 1 | 9.10 |
| CHEMBL327320 | — | — | 1 | 9.00 |
| CHEMBL135 | ESTRADIOL | 4.0 | 1 | 8.89 |
| CHEMBL125362 | — | — | 1 | 8.40 |
| CHEMBL123025 | — | — | 1 | 8.40 |
| CHEMBL93705 | — | — | 1 | 8.40 |
| CHEMBL124482 | — | — | 1 | 8.30 |
| CHEMBL341367 | — | — | 1 | 7.82 |
| CHEMBL126164 | — | — | 1 | 7.75 |
| CHEMBL331996 | — | — | 1 | 7.68 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL304552 | — | IC50 | = | 0.8 | nM | 9.10 |
| CHEMBL327320 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL135 | ESTRADIOL | IC50 | = | 1.3 | nM | 8.89 |
| CHEMBL125362 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL123025 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL93705 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL124482 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL341367 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL126164 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL331996 | — | IC50 | = | 21.0 | nM | 7.68 |