Assay Detail
Functional
CHEMBL677483
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Inhibitory concentration against normal epithelial HMEC cell line
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HMEC |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Development of potential antitumor agents. Synthesis and biological evaluation of a new set of sulfonamide derivatives as histone deacetylase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 4.65 | 5.02 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL317814 | — | — | 1 | 5.02 |
| CHEMBL147506 | — | — | 1 | 4.80 |
| CHEMBL98669 | — | — | 1 | 4.70 |
| CHEMBL99 | TRICHOSTATIN | 1.0 | 1 | 4.50 |
| CHEMBL353629 | — | — | 1 | 4.43 |
| CHEMBL353658 | — | — | 1 | 4.42 |
| CHEMBL148968 | — | — | 1 | - |
| CHEMBL148313 | — | — | 1 | - |
| CHEMBL346414 | — | — | 1 | - |
| CHEMBL168668 | — | — | 1 | - |
| CHEMBL27759 | ENTINOSTAT | 3.0 | 1 | - |
| CHEMBL149444 | — | — | 1 | - |
| CHEMBL149172 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL317814 | — | IC50 | = | 9500.0 | nM | 5.02 |
| CHEMBL147506 | — | IC50 | = | 16000.0 | nM | 4.80 |
| CHEMBL98669 | — | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL99 | TRICHOSTATIN | IC50 | = | 32000.0 | nM | 4.50 |
| CHEMBL353629 | — | IC50 | = | 37000.0 | nM | 4.43 |
| CHEMBL353658 | — | IC50 | = | 38000.0 | nM | 4.42 |
| CHEMBL148968 | — | IC50 | > | 37000.0 | nM | - |
| CHEMBL148313 | — | IC50 | > | 37000.0 | nM | - |
| CHEMBL346414 | — | IC50 | > | 41000.0 | nM | - |
| CHEMBL168668 | — | IC50 | > | 37000.0 | nM | - |
| CHEMBL27759 | ENTINOSTAT | IC50 | > | 37000.0 | nM | - |
| CHEMBL149444 | — | IC50 | > | 37000.0 | nM | - |
| CHEMBL149172 | — | IC50 | > | 36000.0 | nM | - |