Assay Detail
Binding
CHEMBL677547
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Compound was evaluated for its ability to displace [3H]WIN-35428 binding in rat caudate-putamen
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Caudate-putamen |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Sodium-dependent dopamine transporter (CHEMBL338) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Novel 3 alpha-(diphenylmethoxy)tropane analogs: potent dopamine uptake inhibitors without cocaine-like behavioral profiles.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 9 | 7.03 | 7.94 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL281594 | VANOXERINE | 3.0 | 1 | 7.94 |
| CHEMBL543113 | — | — | 1 | 7.93 |
| CHEMBL541825 | — | — | 1 | 7.70 |
| CHEMBL3085569 | — | — | 1 | 7.52 |
| CHEMBL557818 | — | — | 1 | 7.11 |
| CHEMBL1201203 | BENZTROPINE | 4.0 | 1 | 6.93 |
| CHEMBL370805 | COCAINE | 4.0 | 1 | 6.41 |
| CHEMBL310310 | — | — | 1 | 6.07 |
| CHEMBL545227 | — | — | 1 | 5.70 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL281594 | VANOXERINE | Ki | = | 11.6 | nM | 7.94 |
| CHEMBL543113 | — | Ki | = | 11.8 | nM | 7.93 |
| CHEMBL541825 | — | Ki | = | 20.0 | nM | 7.70 |
| CHEMBL3085569 | — | Ki | = | 30.0 | nM | 7.52 |
| CHEMBL557818 | — | Ki | = | 78.4 | nM | 7.11 |
| CHEMBL1201203 | BENZTROPINE | Ki | = | 118.0 | nM | 6.93 |
| CHEMBL370805 | COCAINE | Ki | = | 388.0 | nM | 6.41 |
| CHEMBL310310 | — | Ki | = | 854.0 | nM | 6.07 |
| CHEMBL545227 | — | Ki | = | 2000.0 | nM | 5.70 |