Assay Detail
Binding
CHEMBL677548
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of [3H]DA reuptake at dopamine transporter in rat striatum
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Striatum |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Sodium-dependent dopamine transporter (CHEMBL338) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Thiophene derivatives: a new series of potent norepinephrine and serotonin reuptake inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 12 | 6.09 | 6.59 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL370805 | COCAINE | 4.0 | 1 | 6.59 |
| CHEMBL331565 | — | — | 1 | 6.57 |
| CHEMBL119477 | — | — | 1 | 6.43 |
| CHEMBL117047 | — | — | 1 | 6.39 |
| CHEMBL174854 | — | — | 1 | 6.37 |
| CHEMBL367744 | — | — | 1 | 6.21 |
| CHEMBL173834 | — | — | 1 | 5.99 |
| CHEMBL369497 | — | — | 1 | 5.78 |
| CHEMBL366383 | — | — | 1 | 5.76 |
| CHEMBL366993 | — | — | 1 | 5.64 |
| CHEMBL175338 | — | — | 1 | 5.21 |
| CHEMBL173835 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL370805 | COCAINE | Ki | = | 259.0 | nM | 6.59 |
| CHEMBL331565 | — | Ki | = | 268.0 | nM | 6.57 |
| CHEMBL119477 | — | Ki | = | 368.0 | nM | 6.43 |
| CHEMBL117047 | — | Ki | = | 403.0 | nM | 6.39 |
| CHEMBL174854 | — | Ki | = | 428.0 | nM | 6.37 |
| CHEMBL367744 | — | Ki | = | 610.0 | nM | 6.21 |
| CHEMBL173834 | — | Ki | = | 1020.0 | nM | 5.99 |
| CHEMBL369497 | — | Ki | = | 1678.0 | nM | 5.78 |
| CHEMBL366383 | — | Ki | = | 1750.0 | nM | 5.76 |
| CHEMBL366993 | — | Ki | = | 2300.0 | nM | 5.64 |
| CHEMBL175338 | — | Ki | = | 6140.0 | nM | 5.21 |
| CHEMBL173835 | — | Ki | ~ | 3000.0 | nM | - |