Assay Detail
Binding
CHEMBL677551
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Ability to displace [3H]WIN-35 radioligand for the dopamine transporter 428 DAT in rat brain
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Brain |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Sodium-dependent dopamine transporter (CHEMBL338) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Enantioselective synthesis of S-(+)-2beta-carboalkoxy-3alpha-[bis(4-fluorophenyl)methoxy]tropanes as novel probes for the dopamine transporter.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 5 | 7.73 | 7.95 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL317757 | DIFLUOROBENZTROPINE | — | 1 | 7.95 |
| CHEMBL21859 | — | — | 1 | 7.89 |
| CHEMBL281388 | — | — | 1 | 7.78 |
| CHEMBL428704 | — | — | 1 | 7.63 |
| CHEMBL283154 | — | — | 1 | 7.40 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL317757 | DIFLUOROBENZTROPINE | Ki | = | 11.2 | nM | 7.95 |
| CHEMBL21859 | — | Ki | = | 12.9 | nM | 7.89 |
| CHEMBL281388 | — | Ki | = | 16.8 | nM | 7.78 |
| CHEMBL428704 | — | Ki | = | 23.3 | nM | 7.63 |
| CHEMBL283154 | — | Ki | = | 40.2 | nM | 7.40 |