Assay Detail
Binding
CHEMBL677556
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Displacement of [3H]WIN-35428 binding to the dopamine transporter (DAT) in Rat Caudate Putamen
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Sodium-dependent dopamine transporter (CHEMBL338) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
3'-Chloro-3 alpha-(diphenylmethoxy)tropane but not 4'-chloro-3 alpha-(diphenylmethoxy)tropane produces a cocaine-like behavioral profile.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 12 | 6.95 | 7.67 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3084870 | — | — | 1 | 7.67 |
| CHEMBL310310 | — | — | 1 | 7.52 |
| CHEMBL120901 | — | — | 1 | 7.50 |
| CHEMBL3084909 | — | — | 1 | 7.32 |
| CHEMBL3084869 | — | — | 1 | 7.30 |
| CHEMBL3084907 | — | — | 1 | 7.16 |
| CHEMBL1201203 | BENZTROPINE | 4.0 | 1 | 6.93 |
| CHEMBL3084901 | — | — | 1 | 6.73 |
| CHEMBL3084910 | — | — | 1 | 6.64 |
| CHEMBL3084878 | — | — | 1 | 6.51 |
| CHEMBL370805 | COCAINE | 4.0 | 1 | 6.41 |
| CHEMBL3084891 | AMINOBENZTROPINE | — | 1 | 5.74 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3084870 | — | Ki | = | 21.6 | nM | 7.67 |
| CHEMBL310310 | — | Ki | = | 30.0 | nM | 7.52 |
| CHEMBL120901 | — | Ki | = | 32.0 | nM | 7.50 |
| CHEMBL3084909 | — | Ki | = | 47.4 | nM | 7.32 |
| CHEMBL3084869 | — | Ki | = | 50.0 | nM | 7.30 |
| CHEMBL3084907 | — | Ki | = | 68.5 | nM | 7.16 |
| CHEMBL1201203 | BENZTROPINE | Ki | = | 118.0 | nM | 6.93 |
| CHEMBL3084901 | — | Ki | = | 187.0 | nM | 6.73 |
| CHEMBL3084910 | — | Ki | = | 228.0 | nM | 6.64 |
| CHEMBL3084878 | — | Ki | = | 309.0 | nM | 6.51 |
| CHEMBL370805 | COCAINE | Ki | = | 388.0 | nM | 6.41 |
| CHEMBL3084891 | AMINOBENZTROPINE | Ki | = | 1840.0 | nM | 5.74 |