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Assay Detail

CHEMBL677793

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Binding
Inhibition of estrone sulfatase (ES)
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 8 — Homologous single protein target
Curated By Expert

Target

Steryl-sulfatase (CHEMBL3559)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Hydrophobicity, a physicochemical factor in the inhibition of the enzyme estrone sulfatase (ES).
Ahmed S, James K, Owen CP, Patel CK, Patel M.
Bioorg Med Chem Lett (2001) 11 : 2525 -2528
PubMed 11549461 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 13 4.99 6.30

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL122708 EMATE 1 6.30
CHEMBL84380 1 5.47
CHEMBL82860 1 5.30
CHEMBL315712 1 5.25
CHEMBL11185 1 4.92
CHEMBL82470 1 4.89
CHEMBL315972 1 4.68
CHEMBL85467 1 4.48
CHEMBL85681 1 4.40
CHEMBL304708 1 4.20
CHEMBL85506 1 -
CHEMBL82508 1 -
CHEMBL85468 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL122708 EMATE IC50 = 500.0 nM 6.30
CHEMBL84380 IC50 = 3400.0 nM 5.47
CHEMBL82860 IC50 = 5000.0 nM 5.30
CHEMBL315712 IC50 = 5600.0 nM 5.25
CHEMBL11185 IC50 = 12000.0 nM 4.92
CHEMBL82470 IC50 = 13000.0 nM 4.89
CHEMBL315972 IC50 = 20900.0 nM 4.68
CHEMBL85467 IC50 = 33000.0 nM 4.48
CHEMBL85681 IC50 = 39800.0 nM 4.40
CHEMBL304708 IC50 = 63000.0 nM 4.20
CHEMBL85506 IC50 = 302000.0 nM -
CHEMBL82508 IC50 = 254000.0 nM -
CHEMBL85468 IC50 = 263000.0 nM -