Assay Detail
Binding
CHEMBL677832
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Inhibitory activity against epidermal growth factor receptor tyrosine kinase.
35
Total Activities
35
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Use of a pharmacophore model for the design of EGF-R tyrosine kinase inhibitors: 4-(phenylamino)pyrazolo[3,4-d]pyrimidines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 35 | 7.11 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL121954 | — | — | 1 | 9.00 |
| CHEMBL332906 | — | — | 1 | 8.70 |
| CHEMBL332612 | — | — | 1 | 8.30 |
| CHEMBL332882 | — | — | 1 | 8.30 |
| CHEMBL118130 | — | — | 1 | 8.22 |
| CHEMBL29197 | — | — | 1 | 8.22 |
| CHEMBL122245 | — | — | 1 | 8.15 |
| CHEMBL121796 | — | — | 1 | 8.15 |
| CHEMBL120979 | — | — | 1 | 8.10 |
| CHEMBL123189 | — | — | 1 | 8.10 |
| CHEMBL122182 | — | — | 1 | 8.10 |
| CHEMBL119977 | — | — | 1 | 7.72 |
| CHEMBL331906 | — | — | 1 | 7.58 |
| CHEMBL333231 | — | — | 1 | 7.58 |
| CHEMBL332765 | — | — | 1 | 7.54 |
| CHEMBL122411 | — | — | 1 | 7.52 |
| CHEMBL332333 | — | — | 1 | 7.24 |
| CHEMBL121260 | — | — | 1 | 7.08 |
| CHEMBL332971 | — | — | 1 | 7.02 |
| CHEMBL120069 | — | — | 1 | 6.89 |
| CHEMBL120319 | — | — | 1 | 6.89 |
| CHEMBL121190 | — | — | 1 | 6.80 |
| CHEMBL122068 | — | — | 1 | 6.66 |
| CHEMBL118904 | — | — | 1 | 6.57 |
| CHEMBL420885 | — | — | 1 | 6.57 |
| CHEMBL333038 | — | — | 1 | 6.48 |
| CHEMBL122243 | — | — | 1 | 6.10 |
| CHEMBL119982 | — | — | 1 | 6.06 |
| CHEMBL319540 | — | — | 1 | 5.57 |
| CHEMBL65063 | — | — | 1 | 5.57 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL121954 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL332906 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL332612 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL332882 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL118130 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL29197 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL122245 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL121796 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL120979 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL123189 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL122182 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL119977 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL331906 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL333231 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL332765 | — | IC50 | = | 29.0 | nM | 7.54 |
| CHEMBL122411 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL332333 | — | IC50 | = | 58.0 | nM | 7.24 |
| CHEMBL121260 | — | IC50 | = | 84.0 | nM | 7.08 |
| CHEMBL332971 | — | IC50 | = | 96.0 | nM | 7.02 |
| CHEMBL120069 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL120319 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL121190 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL122068 | — | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL118904 | — | IC50 | = | 270.0 | nM | 6.57 |
| CHEMBL420885 | — | IC50 | = | 270.0 | nM | 6.57 |
| CHEMBL333038 | — | IC50 | = | 330.0 | nM | 6.48 |
| CHEMBL122243 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL119982 | — | IC50 | = | 870.0 | nM | 6.06 |
| CHEMBL319540 | — | IC50 | = | 2710.0 | nM | 5.57 |
| CHEMBL65063 | — | IC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL62756 | — | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL334026 | — | IC50 | = | 24200.0 | nM | 4.62 |
| CHEMBL306081 | — | IC50 | = | 27000.0 | nM | 4.57 |
| CHEMBL120667 | — | IC50 | = | 450000.0 | nM | - |
| CHEMBL120703 | — | IC50 | > | 10000.0 | nM | - |