Assay Detail
Binding
CHEMBL677833
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro inhibition of Epidermal growth factor receptor tyrosine kinase isolated from A431 (human carcinoma).
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
The combi-targeting concept: chemical dissection of the dual targeting properties of a series of "combi-triazenes".
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 21 | 6.65 | 7.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL134312 | — | — | 1 | 7.96 |
| CHEMBL136491 | — | — | 1 | 7.85 |
| CHEMBL133023 | — | — | 1 | 7.62 |
| CHEMBL424093 | — | — | 1 | 7.60 |
| CHEMBL137534 | — | — | 1 | 7.42 |
| CHEMBL137617 | — | — | 1 | 7.41 |
| CHEMBL52765 | — | — | 1 | 7.36 |
| CHEMBL137364 | — | — | 1 | 7.19 |
| CHEMBL136674 | — | — | 1 | 7.15 |
| CHEMBL133024 | — | — | 1 | 7.00 |
| CHEMBL343352 | — | — | 1 | 6.70 |
| CHEMBL137189 | — | — | 1 | 6.70 |
| CHEMBL138125 | — | — | 1 | 6.62 |
| CHEMBL137788 | — | — | 1 | 6.47 |
| CHEMBL137027 | — | — | 1 | 6.32 |
| CHEMBL332096 | — | — | 1 | 6.29 |
| CHEMBL336113 | — | — | 1 | 6.00 |
| CHEMBL135592 | — | — | 1 | 5.10 |
| CHEMBL136492 | — | — | 1 | 5.08 |
| CHEMBL137635 | — | — | 1 | 5.03 |
| CHEMBL344652 | — | — | 1 | 4.88 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL134312 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL136491 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL133023 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL424093 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL137534 | — | IC50 | = | 38.0 | nM | 7.42 |
| CHEMBL137617 | — | IC50 | = | 39.0 | nM | 7.41 |
| CHEMBL52765 | — | IC50 | = | 44.0 | nM | 7.36 |
| CHEMBL137364 | — | IC50 | = | 64.0 | nM | 7.19 |
| CHEMBL136674 | — | IC50 | = | 71.0 | nM | 7.15 |
| CHEMBL133024 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL343352 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL137189 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL138125 | — | IC50 | = | 238.0 | nM | 6.62 |
| CHEMBL137788 | — | IC50 | = | 335.0 | nM | 6.47 |
| CHEMBL137027 | — | IC50 | = | 482.0 | nM | 6.32 |
| CHEMBL332096 | — | IC50 | = | 508.0 | nM | 6.29 |
| CHEMBL336113 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL135592 | — | IC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL136492 | — | IC50 | = | 8400.0 | nM | 5.08 |
| CHEMBL137635 | — | IC50 | = | 9300.0 | nM | 5.03 |
| CHEMBL344652 | — | IC50 | = | 13350.0 | nM | 4.88 |