Assay Detail
Binding
CHEMBL677871
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Binding affinity for Human Estrogen receptor-alpha
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
2-Phenylspiroindenes: a novel class of selective estrogen receptor modulators (SERMs).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 7.97 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL267385 | — | — | 1 | 9.00 |
| CHEMBL81 | RALOXIFENE | 4.0 | 1 | 8.74 |
| CHEMBL281499 | — | — | 1 | 8.37 |
| CHEMBL145576 | — | — | 1 | 7.72 |
| CHEMBL144897 | — | — | 1 | 7.62 |
| CHEMBL24950 | — | — | 1 | 7.55 |
| CHEMBL144431 | — | — | 1 | 7.51 |
| CHEMBL439806 | — | — | 1 | 7.24 |
| CHEMBL345000 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL267385 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL81 | RALOXIFENE | IC50 | = | 1.8 | nM | 8.74 |
| CHEMBL281499 | — | IC50 | = | 4.3 | nM | 8.37 |
| CHEMBL145576 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL144897 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL24950 | — | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL144431 | — | IC50 | = | 31.0 | nM | 7.51 |
| CHEMBL439806 | — | IC50 | = | 58.0 | nM | 7.24 |
| CHEMBL345000 | — | IC50 | > | 10000.0 | nM | - |