Assay Detail
Binding
CHEMBL677876
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Relative binding affinity for human estrogen receptor alpha compared to [3H]estradiol
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Novel estrogen receptor ligands based on an anthranylaldoxime structure: role of the phenol-type pseudocycle in the binding process.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 5 | 9.04 | 9.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL335465 | — | — | 1 | 9.82 |
| CHEMBL128227 | — | — | 1 | 9.33 |
| CHEMBL128654 | — | — | 1 | 8.96 |
| CHEMBL131163 | — | — | 1 | 8.66 |
| CHEMBL130030 | — | — | 1 | 8.43 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL335465 | — | Ki | = | 0.15 | nM | 9.82 |
| CHEMBL128227 | — | Ki | = | 0.47 | nM | 9.33 |
| CHEMBL128654 | — | Ki | = | 1.1 | nM | 8.96 |
| CHEMBL131163 | — | Ki | = | 2.2 | nM | 8.66 |
| CHEMBL130030 | — | Ki | = | 3.7 | nM | 8.43 |