Assay Detail
Binding
CHEMBL677880
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In vitro inhibitory activity against epidermal growth factor receptor
39
Total Activities
39
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
4-(Phenylamino)pyrrolopyrimidines: potent and selective, ATP site directed inhibitors of the EGF-receptor protein tyrosine kinase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 39 | 6.33 | 8.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL29197 | — | — | 1 | 8.40 |
| CHEMBL306315 | — | — | 1 | 8.22 |
| CHEMBL311129 | — | — | 1 | 8.00 |
| CHEMBL74722 | — | — | 1 | 7.60 |
| CHEMBL306081 | — | — | 1 | 7.57 |
| CHEMBL75177 | — | — | 1 | 7.54 |
| CHEMBL72393 | — | — | 1 | 7.34 |
| CHEMBL307209 | — | — | 1 | 7.02 |
| CHEMBL74481 | — | — | 1 | 6.96 |
| CHEMBL73406 | — | — | 1 | 6.77 |
| CHEMBL75208 | — | — | 1 | 6.70 |
| CHEMBL308593 | — | — | 1 | 6.64 |
| CHEMBL268868 | DAPH | — | 1 | 6.52 |
| CHEMBL433305 | — | — | 1 | 6.51 |
| CHEMBL440873 | — | — | 1 | 6.44 |
| CHEMBL72322 | — | — | 1 | 6.38 |
| CHEMBL76444 | — | — | 1 | 6.30 |
| CHEMBL308582 | — | — | 1 | 6.26 |
| CHEMBL73710 | — | — | 1 | 6.25 |
| CHEMBL307026 | — | — | 1 | 6.24 |
| CHEMBL307062 | — | — | 1 | 6.09 |
| CHEMBL431191 | — | — | 1 | 6.07 |
| CHEMBL421686 | — | — | 1 | 5.97 |
| CHEMBL73301 | — | — | 1 | 5.92 |
| CHEMBL74778 | — | — | 1 | 5.90 |
| CHEMBL306029 | — | — | 1 | 5.72 |
| CHEMBL75049 | — | — | 1 | 5.72 |
| CHEMBL307599 | — | — | 1 | 5.68 |
| CHEMBL76116 | — | — | 1 | 5.60 |
| CHEMBL4106341 | — | — | 1 | 5.16 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL29197 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL306315 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL311129 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL74722 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL306081 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL75177 | — | IC50 | = | 29.0 | nM | 7.54 |
| CHEMBL72393 | — | IC50 | = | 46.0 | nM | 7.34 |
| CHEMBL307209 | — | IC50 | = | 96.0 | nM | 7.02 |
| CHEMBL74481 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL73406 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL75208 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL308593 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL268868 | DAPH | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL433305 | — | IC50 | = | 310.0 | nM | 6.51 |
| CHEMBL440873 | — | IC50 | = | 360.0 | nM | 6.44 |
| CHEMBL72322 | — | IC50 | = | 420.0 | nM | 6.38 |
| CHEMBL76444 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL308582 | — | IC50 | = | 550.0 | nM | 6.26 |
| CHEMBL73710 | — | IC50 | = | 560.0 | nM | 6.25 |
| CHEMBL307026 | — | IC50 | = | 570.0 | nM | 6.24 |
| CHEMBL307062 | — | IC50 | = | 820.0 | nM | 6.09 |
| CHEMBL431191 | — | IC50 | = | 860.0 | nM | 6.07 |
| CHEMBL421686 | — | IC50 | = | 1080.0 | nM | 5.97 |
| CHEMBL73301 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL74778 | — | IC50 | = | 1250.0 | nM | 5.90 |
| CHEMBL306029 | — | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL75049 | — | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL307599 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL76116 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL4106341 | — | IC50 | = | 6920.0 | nM | 5.16 |
| CHEMBL431001 | — | IC50 | = | 16300.0 | nM | 4.79 |
| CHEMBL74645 | — | IC50 | = | 25700.0 | nM | 4.59 |
| CHEMBL73625 | — | IC50 | = | 75100.0 | nM | 4.12 |
| CHEMBL309937 | — | IC50 | = | 77500.0 | nM | 4.11 |
| CHEMBL310923 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL72984 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL72560 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL73402 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL72976 | — | IC50 | > | 100000.0 | nM | - |