Assay Detail
Binding
CHEMBL678047
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of [35S]-TBPS binding to rat cortical membranes after 60 minute pre-incubation with radioligand
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Subcellular | Membrane |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Target
GABA-A receptor; anion channel (CHEMBL1907607) ↗| Type | PROTEIN COMPLEX GROUP |
| Organism | Rattus norvegicus |
Publication
Novel site-directed affinity ligands for GABA-gated chloride channels: synthesis, characterization, and molecular modeling of 1-(isothiocyanatophenyl)-4-tert-butyl-2,6,7-trioxabicyclo[2.2.2]octanes .
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 5.81 | 7.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL38835 | — | — | 1 | 7.05 |
| CHEMBL39302 | — | — | 1 | 5.27 |
| CHEMBL39353 | — | — | 1 | 5.12 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL38835 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL39302 | — | IC50 | = | 5400.0 | nM | 5.27 |
| CHEMBL39353 | — | IC50 | = | 7500.0 | nM | 5.12 |