Assay Detail
Binding
CHEMBL678070
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Inhibition of [125I]ET1 binding to cloned human ET-A receptor
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
1,3-Diarylindan-2-carboxylic acids, potent and selective non-peptide endothelin receptor antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 6 | 7.31 | 9.37 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL8823 | SB-209670 | — | 1 | 9.37 |
| CHEMBL39142 | — | — | 1 | 7.95 |
| CHEMBL41087 | — | — | 1 | 7.82 |
| CHEMBL38537 | — | — | 1 | 7.37 |
| CHEMBL290026 | — | — | 1 | 6.38 |
| CHEMBL39171 | — | — | 1 | 4.95 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL8823 | SB-209670 | Ki | = | 0.43 | nM | 9.37 |
| CHEMBL39142 | — | Ki | = | 11.3 | nM | 7.95 |
| CHEMBL41087 | — | Ki | = | 15.0 | nM | 7.82 |
| CHEMBL38537 | — | Ki | = | 43.0 | nM | 7.37 |
| CHEMBL290026 | — | Ki | = | 422.0 | nM | 6.38 |
| CHEMBL39171 | — | Ki | = | 11222.0 | nM | 4.95 |