Assay Detail
Binding
CHEMBL678092
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Binding affinity for human estrogen receptor beta
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Estrogen receptor ligands. Part 6: Synthesis and binding affinity of dihydrobenzodithiins.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 7.08 | 8.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL135 | ESTRADIOL | 4.0 | 1 | 8.96 |
| CHEMBL327320 | — | — | 1 | 7.42 |
| CHEMBL304552 | — | — | 1 | 7.35 |
| CHEMBL123025 | — | — | 1 | 7.06 |
| CHEMBL124482 | — | — | 1 | 6.96 |
| CHEMBL93705 | — | — | 1 | 6.94 |
| CHEMBL125362 | — | — | 1 | 6.79 |
| CHEMBL126164 | — | — | 1 | 6.58 |
| CHEMBL331996 | — | — | 1 | 6.49 |
| CHEMBL341367 | — | — | 1 | 6.23 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL135 | ESTRADIOL | IC50 | = | 1.1 | nM | 8.96 |
| CHEMBL327320 | — | IC50 | = | 38.0 | nM | 7.42 |
| CHEMBL304552 | — | IC50 | = | 45.0 | nM | 7.35 |
| CHEMBL123025 | — | IC50 | = | 87.0 | nM | 7.06 |
| CHEMBL124482 | — | IC50 | = | 111.0 | nM | 6.96 |
| CHEMBL93705 | — | IC50 | = | 115.0 | nM | 6.94 |
| CHEMBL125362 | — | IC50 | = | 161.0 | nM | 6.79 |
| CHEMBL126164 | — | IC50 | = | 266.0 | nM | 6.58 |
| CHEMBL331996 | — | IC50 | = | 326.0 | nM | 6.49 |
| CHEMBL341367 | — | IC50 | = | 583.0 | nM | 6.23 |