Assay Detail
Binding
CHEMBL678128
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Binding affinity for Human Estrogen receptor-beta
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
2-Phenylspiroindenes: a novel class of selective estrogen receptor modulators (SERMs).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 7.90 | 8.72 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL267385 | — | — | 1 | 8.72 |
| CHEMBL281499 | — | — | 1 | 8.68 |
| CHEMBL145576 | — | — | 1 | 8.23 |
| CHEMBL81 | RALOXIFENE | 4.0 | 1 | 7.92 |
| CHEMBL144431 | — | — | 1 | 7.92 |
| CHEMBL144897 | — | — | 1 | 7.68 |
| CHEMBL24950 | — | — | 1 | 7.64 |
| CHEMBL439806 | — | — | 1 | 6.37 |
| CHEMBL345000 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL267385 | — | IC50 | = | 1.9 | nM | 8.72 |
| CHEMBL281499 | — | IC50 | = | 2.1 | nM | 8.68 |
| CHEMBL145576 | — | IC50 | = | 5.9 | nM | 8.23 |
| CHEMBL81 | RALOXIFENE | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL144431 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL144897 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL24950 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL439806 | — | IC50 | = | 429.0 | nM | 6.37 |
| CHEMBL345000 | — | IC50 | > | 10000.0 | nM | - |