Assay Detail
Binding
CHEMBL678131
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Inhibitory concentration against estrogen receptor 2 using radioligand binding assay.
26
Total Activities
26
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Estrogen receptor modulators: identification and structure-activity relationships of potent ERalpha-selective tetrahydroisoquinoline ligands.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 26 | 6.55 | 7.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2113354 | — | — | 1 | 7.89 |
| CHEMBL2137046 | — | — | 1 | 7.68 |
| CHEMBL135 | ESTRADIOL | 4.0 | 1 | 7.62 |
| CHEMBL101807 | — | — | 1 | 6.98 |
| CHEMBL319211 | — | — | 1 | 6.91 |
| CHEMBL316080 | — | — | 1 | 6.78 |
| CHEMBL328388 | — | — | 1 | 6.72 |
| CHEMBL328810 | — | — | 1 | 6.70 |
| CHEMBL101997 | — | — | 1 | 6.69 |
| CHEMBL98558 | — | — | 1 | 6.64 |
| CHEMBL1116 | RALOXIFENE HYDROCHLORIDE | 4.0 | 1 | 6.58 |
| CHEMBL319678 | — | — | 1 | 6.57 |
| CHEMBL103305 | — | — | 1 | 6.55 |
| CHEMBL100763 | — | — | 1 | 6.52 |
| CHEMBL100617 | — | — | 1 | 6.52 |
| CHEMBL101083 | — | — | 1 | 6.50 |
| CHEMBL101382 | — | — | 1 | 6.46 |
| CHEMBL327515 | — | — | 1 | 6.45 |
| CHEMBL103294 | — | — | 1 | 6.40 |
| CHEMBL103650 | — | — | 1 | 6.38 |
| CHEMBL174502 | — | — | 1 | 6.38 |
| CHEMBL100595 | — | — | 1 | 5.96 |
| CHEMBL98470 | — | — | 1 | 5.71 |
| CHEMBL323119 | — | — | 1 | 5.66 |
| CHEMBL101719 | — | — | 1 | 5.51 |
| CHEMBL100231 | — | — | 1 | 5.43 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2113354 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL2137046 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL135 | ESTRADIOL | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL101807 | — | IC50 | = | 104.0 | nM | 6.98 |
| CHEMBL319211 | — | IC50 | = | 123.0 | nM | 6.91 |
| CHEMBL316080 | — | IC50 | = | 166.0 | nM | 6.78 |
| CHEMBL328388 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL328810 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL101997 | — | IC50 | = | 204.0 | nM | 6.69 |
| CHEMBL98558 | — | IC50 | = | 227.0 | nM | 6.64 |
| CHEMBL1116 | RALOXIFENE HYDROCHLORIDE | IC50 | = | 260.0 | nM | 6.58 |
| CHEMBL319678 | — | IC50 | = | 272.0 | nM | 6.57 |
| CHEMBL103305 | — | IC50 | = | 284.0 | nM | 6.55 |
| CHEMBL100763 | — | IC50 | = | 302.0 | nM | 6.52 |
| CHEMBL100617 | — | IC50 | = | 304.0 | nM | 6.52 |
| CHEMBL101083 | — | IC50 | = | 317.0 | nM | 6.50 |
| CHEMBL101382 | — | IC50 | = | 346.0 | nM | 6.46 |
| CHEMBL327515 | — | IC50 | = | 354.0 | nM | 6.45 |
| CHEMBL103294 | — | IC50 | = | 396.0 | nM | 6.40 |
| CHEMBL103650 | — | IC50 | = | 421.0 | nM | 6.38 |
| CHEMBL174502 | — | IC50 | = | 421.0 | nM | 6.38 |
| CHEMBL100595 | — | IC50 | = | 1105.0 | nM | 5.96 |
| CHEMBL98470 | — | IC50 | = | 1974.0 | nM | 5.71 |
| CHEMBL323119 | — | IC50 | = | 2205.0 | nM | 5.66 |
| CHEMBL101719 | — | IC50 | = | 3110.0 | nM | 5.51 |
| CHEMBL100231 | — | IC50 | = | 3687.0 | nM | 5.43 |