Assay Detail
Binding
CHEMBL678244
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Evaluated for the Competitive inhibition of uptake of dopamine transporter
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Sodium-dependent dopamine transporter (CHEMBL338) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
In vivo and in vitro studies on the neurotoxic potential of 6-hydroxydopamine analogs.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 8 | 7.80 | 8.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL131383 | — | — | 1 | 8.52 |
| CHEMBL130653 | — | — | 1 | 8.05 |
| CHEMBL132149 | — | — | 1 | 8.05 |
| CHEMBL337702 | OXIDOPAMINE | 2.0 | 1 | 7.92 |
| CHEMBL28225 | — | — | 1 | 7.80 |
| CHEMBL131384 | — | — | 1 | 7.77 |
| CHEMBL130521 | — | — | 1 | 7.33 |
| CHEMBL132012 | — | — | 1 | 6.95 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL131383 | — | Ki | = | 3.0 | nM | 8.52 |
| CHEMBL130653 | — | Ki | = | 9.0 | nM | 8.05 |
| CHEMBL132149 | — | Ki | = | 9.0 | nM | 8.05 |
| CHEMBL337702 | OXIDOPAMINE | Ki | = | 12.0 | nM | 7.92 |
| CHEMBL28225 | — | Ki | = | 16.0 | nM | 7.80 |
| CHEMBL131384 | — | Ki | = | 17.0 | nM | 7.77 |
| CHEMBL130521 | — | Ki | = | 47.0 | nM | 7.33 |
| CHEMBL132012 | — | Ki | = | 112.0 | nM | 6.95 |