Assay Detail
Binding
CHEMBL678245
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Displacement of [3H]WIN-35428 from dopamine transporter of rat caudate putamen tissue
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Caudate-putamen |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Sodium-dependent dopamine transporter (CHEMBL338) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Synthesis and dopamine transporter binding affinities of 3alpha-benzyl-8-(diarylmethoxyethyl)-8-azabicyclo[3.2.1]octanes.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 11 | 6.91 | 7.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL281594 | VANOXERINE | 3.0 | 1 | 7.92 |
| CHEMBL77867 | — | — | 1 | 7.60 |
| CHEMBL306314 | — | — | 1 | 7.01 |
| CHEMBL76603 | — | — | 1 | 7.00 |
| CHEMBL80245 | — | — | 1 | 6.87 |
| CHEMBL79490 | — | — | 1 | 6.84 |
| CHEMBL370805 | COCAINE | 4.0 | 1 | 6.73 |
| CHEMBL311044 | — | — | 1 | 6.70 |
| CHEMBL306528 | — | — | 1 | 6.66 |
| CHEMBL306359 | — | — | 1 | 6.46 |
| CHEMBL433138 | — | — | 1 | 6.22 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL281594 | VANOXERINE | Ki | = | 12.0 | nM | 7.92 |
| CHEMBL77867 | — | Ki | = | 25.0 | nM | 7.60 |
| CHEMBL306314 | — | Ki | = | 98.0 | nM | 7.01 |
| CHEMBL76603 | — | Ki | = | 99.0 | nM | 7.00 |
| CHEMBL80245 | — | Ki | = | 135.0 | nM | 6.87 |
| CHEMBL79490 | — | Ki | = | 144.0 | nM | 6.84 |
| CHEMBL370805 | COCAINE | Ki | = | 187.0 | nM | 6.73 |
| CHEMBL311044 | — | Ki | = | 198.0 | nM | 6.70 |
| CHEMBL306528 | — | Ki | = | 217.0 | nM | 6.66 |
| CHEMBL306359 | — | Ki | = | 346.0 | nM | 6.46 |
| CHEMBL433138 | — | Ki | = | 595.0 | nM | 6.22 |