Assay Detail
Binding
CHEMBL678247
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In vitro binding affinity in LLC-PK1 cells by Dopamine transporter binding assay by using [125I]IPT as a radioligand
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | LLC-PK1 |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Sodium-dependent dopamine transporter (CHEMBL338) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
New PET imaging agent for the serotonin transporter: [(18)F]ACF (2-[(2-amino-4-chloro-5-fluorophenyl)thio]-N,N-dimethyl-benzenmethanamine).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 5.43 | 6.16 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL23034 | — | — | 1 | 6.16 |
| CHEMBL356755 | — | — | 1 | 5.52 |
| CHEMBL142158 | — | — | 1 | 5.52 |
| CHEMBL142517 | — | — | 1 | 4.50 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL23034 | — | Ki | = | 699.0 | nM | 6.16 |
| CHEMBL356755 | — | Ki | = | 3050.0 | nM | 5.52 |
| CHEMBL142158 | — | Ki | = | 3020.0 | nM | 5.52 |
| CHEMBL142517 | — | Ki | = | 31900.0 | nM | 4.50 |