Assay Detail
Binding
CHEMBL678291
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Tested for inhibitory activity against Epidermal growth factor receptor
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
7-Pyrrolidinyl- and 7-piperidinyl-5-aryl-pyrrolo[2,3-d]pyrimidines--potent inhibitors of the tyrosine kinase c-Src.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 6.46 | 6.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL263528 | — | — | 1 | 6.70 |
| CHEMBL262276 | — | — | 1 | 6.54 |
| CHEMBL168661 | — | — | 1 | 6.47 |
| CHEMBL169780 | — | — | 1 | 6.44 |
| CHEMBL169920 | — | — | 1 | 6.40 |
| CHEMBL172514 | — | — | 1 | 6.21 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL263528 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL262276 | — | IC50 | = | 290.0 | nM | 6.54 |
| CHEMBL168661 | — | IC50 | = | 340.0 | nM | 6.47 |
| CHEMBL169780 | — | IC50 | = | 360.0 | nM | 6.44 |
| CHEMBL169920 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL172514 | — | IC50 | = | 620.0 | nM | 6.21 |