Compound Detail
CHEMBL262276
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Basic Information
| ChEMBL ID | CHEMBL262276 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | HKBVCGJVIFGBEX-UHFFFAOYSA-N |
5
Targets
5
Activities
1
Assay Types
0
PK Parameters
5
Publications
0
Known Names
Molecular Properties
381.4
MW (Da)
2.20
ALogP
8
HBA
2
HBD
106.5
PSA (Ų)
0.67
QED
0
Ro5 Violations
4
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 5 meas. best 9.0
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Proto-oncogene tyrosine-protein kinase Src CHEMBL267 | IC50 | 9.0 | 9.0 | 1.0 | 1 |
| Tyrosine-protein kinase ABL CHEMBL2111414 | IC50 | 7.25 | 7.25 | 56.0 | 1 |
| Tyrosine-protein kinase Lck CHEMBL258 | IC50 | 6.54 | 6.54 | 290.0 | 1 |
| Proto-oncogene tyrosine-protein kinase Src CHEMBL3655 | IC50 | 6.4 | 6.4 | 400.0 | 1 |
| Epidermal growth factor receptor CHEMBL203 | IC50 | 6.1 | 6.1 | 800.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Proto-oncogene tyrosine-protein kinase Src | IC50 | = | 1.0 | nM | 9.0 | Inhibition of c-Src | 18722033 |
| Tyrosine-protein kinase ABL | IC50 | = | 56.0 | nM | 7.25 | Concentration required for inhibition of v-Abl receptor by tyrosine kinase enzym... | 11277536 |
| Tyrosine-protein kinase Lck | IC50 | = | 290.0 | nM | 6.54 | Tested for inhibitory activity against Epidermal growth factor receptor | 11277536 |
| Proto-oncogene tyrosine-protein kinase Src | IC50 | = | 400.0 | nM | 6.4 | Concentration required for inhibition of c-Src mediated phosphorylation of Fak i... | 11277536 |
| Epidermal growth factor receptor | IC50 | = | 800.0 | nM | 6.1 | Concentration required for inhibition of epidermal growth factor receptor (EGF-R... | 11277536 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 11277536 | 10.1016/s0960-894x(01)00080-4 | Proto-oncogene tyrosine-protein kinase Src | 2 |
| 11277536 | 10.1016/s0960-894x(01)00080-4 | Epidermal growth factor receptor | 2 |
| 11277536 | 10.1016/s0960-894x(01)00080-4 | Tyrosine-protein kinase ABL | 1 |
| 11277536 | 10.1016/s0960-894x(01)00080-4 | Tyrosine-protein kinase Lck | 1 |
| 18722033 | 10.1016/j.ejmech.2008.07.002 | Proto-oncogene tyrosine-protein kinase Src | 1 |
Data from ChEMBL 36 via Core Engine