Assay Detail
Functional
CHEMBL700596
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Concentration required for inhibition of c-Src mediated phosphorylation of Fak in IC8.1 fibroblast cell assay
27
Total Activities
27
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Gallus gallus |
| Cell Type | Fibroblast |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Proto-oncogene tyrosine-protein kinase Src (CHEMBL3655) ↗| Type | SINGLE PROTEIN |
| Organism | Gallus gallus |
Publication
7-Pyrrolidinyl- and 7-piperidinyl-5-aryl-pyrrolo[2,3-d]pyrimidines--potent inhibitors of the tyrosine kinase c-Src.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 27 | 5.99 | 6.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL422565 | — | — | 1 | 6.40 |
| CHEMBL262276 | — | — | 1 | 6.40 |
| CHEMBL408683 | — | — | 1 | 6.40 |
| CHEMBL352619 | — | — | 1 | 6.40 |
| CHEMBL169920 | — | — | 1 | 6.30 |
| CHEMBL168661 | — | — | 1 | 6.22 |
| CHEMBL169780 | — | — | 1 | 6.22 |
| CHEMBL352666 | — | — | 1 | 6.16 |
| CHEMBL169064 | — | — | 1 | 6.16 |
| CHEMBL355019 | — | — | 1 | 6.16 |
| CHEMBL171545 | — | — | 1 | 6.10 |
| CHEMBL263528 | — | — | 1 | 6.10 |
| CHEMBL169200 | — | — | 1 | 5.85 |
| CHEMBL354033 | — | — | 1 | 5.57 |
| CHEMBL169065 | — | — | 1 | 5.55 |
| CHEMBL168921 | — | — | 1 | 5.51 |
| CHEMBL169043 | — | — | 1 | 5.48 |
| CHEMBL169939 | — | — | 1 | 5.48 |
| CHEMBL168656 | — | — | 1 | 5.36 |
| CHEMBL172574 | — | — | 1 | - |
| CHEMBL353823 | — | — | 1 | - |
| CHEMBL355322 | — | — | 1 | - |
| CHEMBL169519 | — | — | 1 | - |
| CHEMBL355891 | — | — | 1 | - |
| CHEMBL168462 | — | — | 1 | - |
| CHEMBL352829 | — | — | 1 | - |
| CHEMBL355269 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL422565 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL262276 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL408683 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL352619 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL169920 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL168661 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL169780 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL352666 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL169064 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL355019 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL171545 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL263528 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL169200 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL354033 | — | IC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL169065 | — | IC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL168921 | — | IC50 | = | 3100.0 | nM | 5.51 |
| CHEMBL169043 | — | IC50 | = | 3300.0 | nM | 5.48 |
| CHEMBL169939 | — | IC50 | = | 3300.0 | nM | 5.48 |
| CHEMBL168656 | — | IC50 | = | 4400.0 | nM | 5.36 |
| CHEMBL172574 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL353823 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL355322 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL169519 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL355891 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL168462 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL352829 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL355269 | — | IC50 | > | 5000.0 | nM | - |