Assay Detail
Binding
CHEMBL978937
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Inhibition of c-Src
114
Total Activities
114
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Proto-oncogene tyrosine-protein kinase Src (CHEMBL267) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Docking, 3D-QSAR studies and in silico ADME prediction on c-Src tyrosine kinase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 80 | 7.18 | 9.50 |
| Ki | 34 | 5.54 | 6.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL516062 | — | — | 1 | 9.50 |
| CHEMBL474998 | — | — | 1 | 9.50 |
| CHEMBL263528 | — | — | 1 | 9.00 |
| CHEMBL262276 | — | — | 1 | 9.00 |
| CHEMBL169780 | — | — | 1 | 9.00 |
| CHEMBL169390 | — | — | 1 | 9.00 |
| CHEMBL168382 | — | — | 1 | 8.70 |
| CHEMBL473024 | — | — | 1 | 8.50 |
| CHEMBL169920 | — | — | 1 | 8.50 |
| CHEMBL355330 | — | — | 1 | 8.40 |
| CHEMBL470527 | — | — | 1 | 8.30 |
| CHEMBL168661 | — | — | 1 | 8.20 |
| CHEMBL475156 | — | — | 1 | 8.10 |
| CHEMBL166765 | — | — | 1 | 8.00 |
| CHEMBL515751 | — | — | 1 | 8.00 |
| CHEMBL176702 | — | — | 1 | 8.00 |
| CHEMBL475264 | — | — | 1 | 7.80 |
| CHEMBL475584 | — | — | 1 | 7.70 |
| CHEMBL367442 | — | — | 1 | 7.70 |
| CHEMBL175409 | — | — | 1 | 7.70 |
| CHEMBL470925 | — | — | 1 | 7.70 |
| CHEMBL474656 | — | — | 1 | 7.70 |
| CHEMBL474657 | — | — | 1 | 7.70 |
| CHEMBL473155 | — | — | 1 | 7.70 |
| CHEMBL169064 | — | — | 1 | 7.70 |
| CHEMBL169570 | — | — | 1 | 7.70 |
| CHEMBL474825 | — | — | 1 | 7.60 |
| CHEMBL169200 | — | — | 1 | 7.60 |
| CHEMBL173453 | — | — | 1 | 7.50 |
| CHEMBL424375 | — | — | 1 | 7.50 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL516062 | — | IC50 | = | 0.3162 | nM | 9.50 |
| CHEMBL474998 | — | IC50 | = | 0.3162 | nM | 9.50 |
| CHEMBL169390 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL169780 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL262276 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL263528 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL168382 | — | IC50 | = | 1.995 | nM | 8.70 |
| CHEMBL473024 | — | IC50 | = | 3.162 | nM | 8.50 |
| CHEMBL169920 | — | IC50 | = | 3.162 | nM | 8.50 |
| CHEMBL355330 | — | IC50 | = | 3.981 | nM | 8.40 |
| CHEMBL470527 | — | IC50 | = | 5.012 | nM | 8.30 |
| CHEMBL168661 | — | IC50 | = | 6.31 | nM | 8.20 |
| CHEMBL475156 | — | IC50 | = | 7.943 | nM | 8.10 |
| CHEMBL166765 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL176702 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL515751 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL475264 | — | IC50 | = | 15.85 | nM | 7.80 |
| CHEMBL169064 | — | IC50 | = | 19.95 | nM | 7.70 |
| CHEMBL473155 | — | IC50 | = | 19.95 | nM | 7.70 |
| CHEMBL474657 | — | IC50 | = | 19.95 | nM | 7.70 |
| CHEMBL474656 | — | IC50 | = | 19.95 | nM | 7.70 |
| CHEMBL175409 | — | IC50 | = | 19.95 | nM | 7.70 |
| CHEMBL169570 | — | IC50 | = | 19.95 | nM | 7.70 |
| CHEMBL367442 | — | IC50 | = | 19.95 | nM | 7.70 |
| CHEMBL475584 | — | IC50 | = | 19.95 | nM | 7.70 |
| CHEMBL470925 | — | IC50 | = | 19.95 | nM | 7.70 |
| CHEMBL169200 | — | IC50 | = | 25.12 | nM | 7.60 |
| CHEMBL474825 | — | IC50 | = | 25.12 | nM | 7.60 |
| CHEMBL173453 | — | IC50 | = | 31.62 | nM | 7.50 |
| CHEMBL424375 | — | IC50 | = | 31.62 | nM | 7.50 |
| CHEMBL105436 | — | IC50 | = | 31.62 | nM | 7.50 |
| CHEMBL470731 | — | IC50 | = | 31.62 | nM | 7.50 |
| CHEMBL475414 | — | IC50 | = | 39.81 | nM | 7.40 |
| CHEMBL475355 | — | IC50 | = | 39.81 | nM | 7.40 |
| CHEMBL470746 | — | IC50 | = | 39.81 | nM | 7.40 |
| CHEMBL355191 | — | IC50 | = | 39.81 | nM | 7.40 |
| CHEMBL172973 | — | IC50 | = | 50.12 | nM | 7.30 |
| CHEMBL511320 | — | IC50 | = | 50.12 | nM | 7.30 |
| CHEMBL471575 | — | IC50 | = | 50.12 | nM | 7.30 |
| CHEMBL274732 | — | IC50 | = | 50.12 | nM | 7.30 |
| CHEMBL173478 | — | IC50 | = | 63.1 | nM | 7.20 |
| CHEMBL176815 | — | IC50 | = | 63.1 | nM | 7.20 |
| CHEMBL355269 | — | IC50 | = | 63.1 | nM | 7.20 |
| CHEMBL170724 | — | IC50 | = | 79.43 | nM | 7.10 |
| CHEMBL169065 | — | IC50 | = | 79.43 | nM | 7.10 |
| CHEMBL320417 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL166766 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL475008 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL169757 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL513563 | — | IC50 | = | 100.0 | nM | 7.00 |