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Assay Detail

CHEMBL678314

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Binding
Inhibition of estrone sulfatase
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Expert

Target

Steryl-sulfatase (CHEMBL3559)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Inhibition of estrone sulfatase (ES) by alkyl and cycloalkyl ester derivatives of 4-[(aminosulfonyl)oxy] benzoic acid.
Patel CK, Owen CP, Ahmed S.
Bioorg Med Chem Lett (2004) 14 : 605 -609
PubMed 14741252 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 17 5.41 6.77

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL155465 1 6.77
CHEMBL286738 IROSUSTAT 2.0 1 6.68
CHEMBL349091 1 6.30
CHEMBL122708 EMATE 1 6.30
CHEMBL443552 1 5.77
CHEMBL420395 1 5.47
CHEMBL78282 1 5.42
CHEMBL80330 1 5.32
CHEMBL421505 1 5.30
CHEMBL306782 1 5.23
CHEMBL347202 1 5.03
CHEMBL76374 1 4.98
CHEMBL77121 1 4.88
CHEMBL11185 1 4.86
CHEMBL305637 1 4.65
CHEMBL311899 1 4.50
CHEMBL79227 1 4.50

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL155465 IC50 = 170.0 nM 6.77
CHEMBL286738 IROSUSTAT IC50 = 210.0 nM 6.68
CHEMBL349091 IC50 = 500.0 nM 6.30
CHEMBL122708 EMATE IC50 = 500.0 nM 6.30
CHEMBL443552 IC50 = 1700.0 nM 5.77
CHEMBL420395 IC50 = 3400.0 nM 5.47
CHEMBL78282 IC50 = 3800.0 nM 5.42
CHEMBL80330 IC50 = 4800.0 nM 5.32
CHEMBL421505 IC50 = 5000.0 nM 5.30
CHEMBL306782 IC50 = 5900.0 nM 5.23
CHEMBL347202 IC50 = 9300.0 nM 5.03
CHEMBL76374 IC50 = 10500.0 nM 4.98
CHEMBL77121 IC50 = 13200.0 nM 4.88
CHEMBL11185 IC50 = 13800.0 nM 4.86
CHEMBL305637 IC50 = 22400.0 nM 4.65
CHEMBL311899 IC50 = 31600.0 nM 4.50
CHEMBL79227 IC50 = 31600.0 nM 4.50