Assay Detail
Binding
CHEMBL678350
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Inhibition activity towards human recombinant Endothelin-converting enzyme 1 (hECE-1c) expressed in Cos-7 cells
25
Total Activities
25
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | COS-7 |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Toward an optimal joint recognition of the S1' subsites of endothelin converting enzyme-1 (ECE-1), angiotensin converting enzyme (ACE), and neutral endopeptidase (NEP).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 25 | 6.42 | 7.58 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL285490 | — | — | 1 | 7.58 |
| CHEMBL35643 | — | — | 1 | 7.00 |
| CHEMBL38075 | — | — | 1 | 7.00 |
| CHEMBL288911 | — | — | 1 | 6.96 |
| CHEMBL37841 | — | — | 1 | 6.87 |
| CHEMBL35749 | — | — | 1 | 6.72 |
| CHEMBL289518 | — | — | 1 | 6.72 |
| CHEMBL285204 | — | — | 1 | 6.70 |
| CHEMBL285960 | — | — | 1 | 6.66 |
| CHEMBL290610 | — | — | 1 | 6.60 |
| CHEMBL285447 | — | — | 1 | 6.54 |
| CHEMBL290492 | — | — | 1 | 6.52 |
| CHEMBL288584 | — | — | 1 | 6.52 |
| CHEMBL288814 | — | — | 1 | 6.24 |
| CHEMBL289223 | — | — | 1 | 6.22 |
| CHEMBL2114403 | — | — | 1 | 6.17 |
| CHEMBL37276 | — | — | 1 | 6.17 |
| CHEMBL38249 | — | — | 1 | 6.11 |
| CHEMBL288302 | — | — | 1 | 6.05 |
| CHEMBL37711 | — | — | 1 | 6.04 |
| CHEMBL38235 | — | — | 1 | 6.01 |
| CHEMBL2115345 | — | — | 1 | 5.94 |
| CHEMBL287801 | — | — | 1 | 5.91 |
| CHEMBL287261 | — | — | 1 | 5.81 |
| CHEMBL34876 | — | — | 1 | 5.38 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL285490 | — | Ki | = | 26.0 | nM | 7.58 |
| CHEMBL35643 | — | Ki | = | 100.0 | nM | 7.00 |
| CHEMBL38075 | — | Ki | = | 100.0 | nM | 7.00 |
| CHEMBL288911 | — | Ki | = | 110.0 | nM | 6.96 |
| CHEMBL37841 | — | Ki | = | 135.0 | nM | 6.87 |
| CHEMBL35749 | — | Ki | = | 190.0 | nM | 6.72 |
| CHEMBL289518 | — | Ki | = | 190.0 | nM | 6.72 |
| CHEMBL285204 | — | Ki | = | 200.0 | nM | 6.70 |
| CHEMBL285960 | — | Ki | = | 220.0 | nM | 6.66 |
| CHEMBL290610 | — | Ki | = | 250.0 | nM | 6.60 |
| CHEMBL285447 | — | Ki | = | 290.0 | nM | 6.54 |
| CHEMBL290492 | — | Ki | = | 300.0 | nM | 6.52 |
| CHEMBL288584 | — | Ki | = | 300.0 | nM | 6.52 |
| CHEMBL288814 | — | Ki | = | 580.0 | nM | 6.24 |
| CHEMBL289223 | — | Ki | = | 600.0 | nM | 6.22 |
| CHEMBL2114403 | — | Ki | = | 680.0 | nM | 6.17 |
| CHEMBL37276 | — | Ki | = | 670.0 | nM | 6.17 |
| CHEMBL38249 | — | Ki | = | 780.0 | nM | 6.11 |
| CHEMBL288302 | — | Ki | = | 900.0 | nM | 6.05 |
| CHEMBL37711 | — | Ki | = | 920.0 | nM | 6.04 |
| CHEMBL38235 | — | Ki | = | 980.0 | nM | 6.01 |
| CHEMBL2115345 | — | Ki | = | 1140.0 | nM | 5.94 |
| CHEMBL287801 | — | Ki | = | 1240.0 | nM | 5.91 |
| CHEMBL287261 | — | Ki | = | 1560.0 | nM | 5.81 |
| CHEMBL34876 | — | Ki | = | 4150.0 | nM | 5.38 |