Assay Detail
Functional
CHEMBL678366
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Compound was tested for inhibition of Ent. cloacae 908R in combination with Ceftriaxone (expressed in MIC).
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Enterobacter cloacae |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Design, synthesis, and evaluation of 2 beta-alkenyl penam sulfone acids as inhibitors of beta-lactamases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 5.46 | 6.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL6461 | Ro-481220 | — | 1 | 6.00 |
| CHEMBL124960 | — | — | 1 | 5.70 |
| CHEMBL333078 | — | — | 1 | 5.40 |
| CHEMBL122209 | — | — | 1 | 5.10 |
| CHEMBL123481 | — | — | 1 | 5.10 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL6461 | Ro-481220 | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL124960 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL333078 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL122209 | — | IC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL123481 | — | IC50 | = | 8000.0 | nM | 5.10 |